Global patent index - EP 1017373 A2

EP 1017373 A2 2000-07-12 - REGULATION OF CELLULAR APOPTOSIS USING MODULATORS OF $g(b)-AR RECEPTORS

Title (en)

REGULATION OF CELLULAR APOPTOSIS USING MODULATORS OF $g(b)-AR RECEPTORS

Title (de)

REGULIERUNG DER ZELLAPOPTOSE DURCH BETA-ADRENOREZEPTOR-MODULATOREN

Title (fr)

REGULATION DE L'APOPTOSE CELLULAIRE PAR DES MODULATEURS DE RECEPTEURS $g(b)-AR

Publication

EP 1017373 A2 (FR)

Application

EP 98945354 A

Priority

  • FR 9802030 W
  • FR 9711820 A

Abstract (en)

[origin: FR2768626A1] Use of a beta -adrenergic modulator to obtain an apoptosis-regulating medicament is new. PREFERRED MODULATOR - The beta -adrenergic modulator is a beta 1, beta 2 or beta 3 adrenergic receptor agonist or antagonist. A beta 2 adrenergic receptor agonist is used to inhibit apoptosis of hepatocytes. EXAMPLE - C57BL/6 mice receiving drinking water containing 1.3 mg/l clenbuterol (a specific beta 2-adrenergic receptor) for 18 hours before intra-venous injection with 15 mu g anti-Fas monoclonal antibody Jo2 had a survival time of 200-210 minutes, compared with 150-175 minutes for non-pretreated mice.

IPC 1-7 (main, further and additional classification)

A61K 31/00; A61K 31/135

IPC 8 full level (invention and additional information)

C07K 16/28 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07K 16/2878 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9915158A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2768626 A1 19990326; FR 2768626 B1 20001117; CA 2304843 A1 19990401; EP 1017373 A2 20000712; US 6333359 B1 20011225; WO 9915158 A2 19990401; WO 9915158 A3 19990610

INPADOC legal status

2003-08-13 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030117

2002-10-23 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020906

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000406

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE