EP 1017373 A2 20000712 - REGULATION OF CELLULAR APOPTOSIS USING MODULATORS OF $g(b)-AR RECEPTORS
Title (en)
REGULATION OF CELLULAR APOPTOSIS USING MODULATORS OF $g(b)-AR RECEPTORS
Title (de)
REGULIERUNG DER ZELLAPOPTOSE DURCH BETA-ADRENOREZEPTOR-MODULATOREN
Title (fr)
REGULATION DE L'APOPTOSE CELLULAIRE PAR DES MODULATEURS DE RECEPTEURS $g(b)-AR
Publication
Application
Priority
- FR 9802030 W 19980922
- FR 9711820 A 19970923
Abstract (en)
[origin: FR2768626A1] Use of a beta -adrenergic modulator to obtain an apoptosis-regulating medicament is new. PREFERRED MODULATOR - The beta -adrenergic modulator is a beta 1, beta 2 or beta 3 adrenergic receptor agonist or antagonist. A beta 2 adrenergic receptor agonist is used to inhibit apoptosis of hepatocytes. EXAMPLE - C57BL/6 mice receiving drinking water containing 1.3 mg/l clenbuterol (a specific beta 2-adrenergic receptor) for 18 hours before intra-venous injection with 15 mu g anti-Fas monoclonal antibody Jo2 had a survival time of 200-210 minutes, compared with 150-175 minutes for non-pretreated mice.
IPC 1-7
IPC 8 full level
C07K 16/28 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
C07K 16/2878 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Citation (search report)
See references of WO 9915158A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
FR 2768626 A1 19990326; FR 2768626 B1 20001117; CA 2304843 A1 19990401; EP 1017373 A2 20000712; US 6333359 B1 20011225; WO 9915158 A2 19990401; WO 9915158 A3 19990610
DOCDB simple family (application)
FR 9711820 A 19970923; CA 2304843 A 19980922; EP 98945354 A 19980922; FR 9802030 W 19980922; US 50919400 A 20000629