Global Patent Index - EP 1017374 A2

EP 1017374 A2 2000-07-12 - G2 CHECKPOINT INHIBITORS AND ASSAY

Title (en)

G2 CHECKPOINT INHIBITORS AND ASSAY

Title (de)

G2 CHECKPOINT HEMMER UND TEST

Title (fr)

INHIBITEURS DES POINTS DE CONTROLE G2 ET DOSAGE

Publication

EP 1017374 A2 (EN)

Application

EP 98946177 A

Priority

  • CA 9800914 W
  • CA 2216559 A

Abstract (en)

[origin: WO9915157A2] Compounds are provided that inhibit the G2 checkpoint in the cell cycle and are useful for sensitizing cells to killing by DNA damaging agents. Also provided is an assay for G2 checkpoint inhibitors which includes applying a DNA damaging agent to cells which are incapable of G1 arrest but will arrest at G2 in response to the DNA damaging agent and determining whether the cells do not arrest at G2 and proceed to mitosis after application of a sample to be tested. The assay may employ mitotic cell specific monoclonal antibodies. Also provided is a method of identifying phosphorylated proteins involved in the mitotic cycle of a cell in which proteins of a cell treated with a G2 checkpoint inhibitor are compared to proteins of a cell not so treated.

IPC 1-7 (main, further and additional classification)

A61K 31/00

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01)

CPC (invention and additional information)

A61K 31/00 (2013.01)

Citation (search report)

See references of WO 9915157A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9915157 A2 19990401; WO 9915157 A3 19990923; AU 9333498 A 19990412; CA 2216559 A1 19990325; EP 1017374 A2 20000712

INPADOC legal status


2002-12-18 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020611

2002-03-20 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020131

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000425

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE