EP 1017658 A1 20000712 - BENZYL-BIPHENYLS AND ANALOGOUS COMPOUNDS AND THE APPLICATION THEREOF IN ORDER TO TREAT ARTERIOSCLEROSIS AND DYSLIPIDAEMIA
Title (en)
BENZYL-BIPHENYLS AND ANALOGOUS COMPOUNDS AND THE APPLICATION THEREOF IN ORDER TO TREAT ARTERIOSCLEROSIS AND DYSLIPIDAEMIA
Title (de)
BENZYL-BIPHENYLE UND ANALOGE VERBINDUNGEN UND DEREN VERWENDUNG ZUR BEHANDLUNG VON ARTERIOSKLEROSE UND DIYLIPIDÄMIEN
Title (fr)
BENZYLBIPHENYLES ET COMPOSES ANALOGUES ET LEUR UTILISATION POUR LE TRAITEMENT DE L'ARTERIOSCLEROSE ET DES DYSLIPIDEMIES
Publication
Application
Priority
- DE 19741400 A 19970919
- EP 9805731 W 19980909
Abstract (en)
[origin: DE19741400A1] Hydroxylated benzyl-biphenyl derivatives (I) and their salts are new. Benzyl-biphenyl derivatives of formula (I) and their salts are new: A = cycloalkyl, or aryl or heterocyclyl containing up to 4 S, N and/or O atoms (both optionally substituted by 15 groups), D = -L-R<5>; -CR<6>R<7>R<8>; or -X-V-T-R<9>; R<5>, R<6> and R<9> = aryl or heterocyclyl (both optionally substituted by 15 groups); or R<5> and/or R<6> = difluoromethylenedioxy-phenyl or 2-trifluoromethyl-benzofuran-4-, -5-, -6- or -7-yl; R<7> = H, halo or methyl; and R<8> = H, halo, N3, CF3, OH, OCF3, 1-6C alkyl, 1-6C alkoxy or optionally mono- or disubstituted amino; or R<7>+R<8> = O or optionally substituted imino; L = alkylene or alkenylene optionally substituted by OH; T and X = alkylene; or T or X = a bond; V = O, S or optionally substituted imino; E = cycloalkyl, alkyl optionally substituted by cycloalkyl or OH, or phenyl optionally substituted by halo or CF3; R<1> = alkyl substituted by OH or tetrahydropyran-2-yloxy; R<2> = H or alkyl or alkenyl optionally substituted by 8 groups. The full definitions are given in the DEFINITIONS (Full Definitions) Field. An Independent claim is included for the preparation of (I).
IPC 1-7
C07C 33/50; C07C 33/46; C07C 43/178; C07C 69/78; C07D 309/12; C07D 213/64; C07D 211/88; C07D 207/404; C07D 209/48; C07F 7/08; A61K 31/045; A61K 31/075; A61K 31/695; A61K 31/35; A61K 31/40; A61K 31/44; A61K 31/45; C07D 207/40
IPC 8 full level
A61K 31/045 (2006.01); A61K 31/047 (2006.01); A61K 31/075 (2006.01); A61K 31/085 (2006.01); A61K 31/216 (2006.01); A61K 31/351 (2006.01); A61K 31/4015 (2006.01); A61K 31/403 (2006.01); A61K 31/4035 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4465 (2006.01); A61K 31/45 (2006.01); A61K 31/695 (2006.01); A61P 3/06 (2006.01); A61P 9/10 (2006.01); C07C 29/44 (2006.01); C07C 33/46 (2006.01); C07C 33/48 (2006.01); C07C 33/50 (2006.01); C07C 41/16 (2006.01); C07C 43/178 (2006.01); C07C 43/23 (2006.01); C07C 69/76 (2006.01); C07C 69/92 (2006.01); C07D 207/404 (2006.01); C07D 209/48 (2006.01); C07D 211/88 (2006.01); C07D 213/64 (2006.01); C07D 309/12 (2006.01); C07F 7/18 (2006.01)
CPC (source: EP)
A61P 3/06 (2017.12); A61P 9/10 (2017.12); C07C 33/46 (2013.01); C07C 33/486 (2013.01); C07C 33/50 (2013.01); C07C 43/1786 (2013.01); C07C 43/23 (2013.01); C07C 69/92 (2013.01); C07D 209/48 (2013.01); C07D 213/64 (2013.01); C07D 309/12 (2013.01); C07C 2601/02 (2017.04); C07C 2601/08 (2017.04)
Citation (search report)
See references of WO 9915487A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19741400 A1 19990325; AU 1145899 A 19990412; CA 2304274 A1 19990401; EP 1017658 A1 20000712; JP 2001517646 A 20011009; WO 9915487 A1 19990401
DOCDB simple family (application)
DE 19741400 A 19970919; AU 1145899 A 19980909; CA 2304274 A 19980909; EP 9805731 W 19980909; EP 98954266 A 19980909; JP 2000512799 A 19980909