EP 1017687 A1 20000712 - PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2
Title (en)
PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2
Title (de)
VERFAHREN ZUR HERSTELLUNG VON 3-ARYLOXY-4-ARYL-FURAN-2-ONE ALS INHIBITOREN VON COX-2
Title (fr)
PROCEDE DE PREPARATION DE 3-ARYLOXY, 4-ARYL FURAN-2-ONES UTILES COMME INHIBITEURS DE COX-2
Publication
Application
Priority
- GB 9815805 A 19980721
- US 9819642 W 19980921
- US 6069497 P 19970924
Abstract (en)
[origin: WO9915513A1] Described is a process of preparing 3-aryl, 4-aryloxy furan-5- ones which are useful as inhibitors of cyclooxygenase-2(COX-2). Such compounds are useful as anti-inflammatory agents. The process is directed to an asymmetric synthesis which involves: a trisubstituted styrene derivative preparation via Horner-Wadsworth-Emmons reaction and subsequent one pot trifluoromethylation of the allylic alcohol; preparation of the alpha -hydroxyl ketone using Sharpless assymmetric dihydroxylation and Swern oxidation; the esterification of the alpha -hydroxyl ketone with the phenoxy acetic acid; and the Dieckman condensation of the resulting ester.
IPC 1-7
IPC 8 full level
C07D 307/60 (2006.01); C07D 405/10 (2006.01)
CPC (source: EP)
C07D 307/60 (2013.01)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9915513 A1 19990401; AU 2247599 A 19990412; CN 1271352 A 20001025; EA 002690 B1 20020829; EA 200000350 A1 20001030; EP 1017687 A1 20000712; EP 1017687 A4 20011031; JP 2001517661 A 20011009; JP 3516658 B2 20040405; SK 4202000 A3 20001009
DOCDB simple family (application)
US 9819642 W 19980921; AU 2247599 A 19980921; CN 98809463 A 19980921; EA 200000350 A 19980921; EP 98947177 A 19980921; JP 2000512820 A 19980921; SK 4202000 A 19980921