Global Patent Index - EP 1017687 A1

EP 1017687 A1 2000-07-12 - PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2

Title (en)

PROCESS OF MAKING 3-ARYLOXY, 4-ARYL FURAN-2-ONES USEFUL AS INHIBITORS OF COX-2

Title (de)

VERFAHREN ZUR HERSTELLUNG VON 3-ARYLOXY-4-ARYL-FURAN-2-ONE ALS INHIBITOREN VON COX-2

Title (fr)

PROCEDE DE PREPARATION DE 3-ARYLOXY, 4-ARYL FURAN-2-ONES UTILES COMME INHIBITEURS DE COX-2

Publication

EP 1017687 A1 (EN)

Application

EP 98947177 A

Priority

  • GB 9815805 A
  • US 9819642 W
  • US 6069497 P

Abstract (en)

[origin: WO9915513A1] Described is a process of preparing 3-aryl, 4-aryloxy furan-5- ones which are useful as inhibitors of cyclooxygenase-2(COX-2). Such compounds are useful as anti-inflammatory agents. The process is directed to an asymmetric synthesis which involves: a trisubstituted styrene derivative preparation via Horner-Wadsworth-Emmons reaction and subsequent one pot trifluoromethylation of the allylic alcohol; preparation of the alpha -hydroxyl ketone using Sharpless assymmetric dihydroxylation and Swern oxidation; the esterification of the alpha -hydroxyl ketone with the phenoxy acetic acid; and the Dieckman condensation of the resulting ester.

IPC 1-7 (main, further and additional classification)

C07D 307/02; C07D 405/00

IPC 8 full level (invention and additional information)

C07D 307/60 (2006.01); C07D 405/10 (2006.01)

CPC (invention and additional information)

C07D 307/60 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9915513 A1 19990401; AU 2247599 A 19990412; CN 1271352 A 20001025; EA 002690 B1 20020829; EA 200000350 A1 20001030; EP 1017687 A1 20000712; EP 1017687 A4 20011031; JP 2001517661 A 20011009; JP 3516658 B2 20040405; SK 4202000 A3 20001009

INPADOC legal status


2005-08-10 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20050208

2002-06-26 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20020513

2001-10-31 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20010917

2001-10-31 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A4

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-10-31 [RIC1] CLASSIFICATION (CORRECTION)

- Free text: 7C 07D 307/02 A, 7C 07D 405/00 B, 7C 07D 307/60 B

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000425

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-07-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: RO PAYMENT 20000425