Global patent index - EP 1017691 A1

EP 1017691 A1 2000-07-12 - BISETHERS OF 1-OXA, AZA AND THIANAPHTHALEN-2-ONES AS PHOSPHOLAMBAN INHIBITORS

Title (en)

BISETHERS OF 1-OXA, AZA AND THIANAPHTHALEN-2-ONES AS PHOSPHOLAMBAN INHIBITORS

Title (de)

DIETHER VON 1-OXA-, AZA- UND THIANAPHTHALIN-2-ONEN ALS PHOSPHOLAMBANHEMMER

Title (fr)

BISETHERS DE 1-OXA, AZA ET THIANAPHTALENE-2-ONE INHIBITEURS DU PHOSPHOLAMBANE

Publication

EP 1017691 A1 (EN)

Application

EP 98946482 A

Priority

  • FI 9800755 W
  • US 93711997 A
  • US 99015097 A
  • US 10411498 A

Abstract (en)

[origin: WO9915523A1] Therapeutically active compounds of formula (I) or (II), in which R1 is hydrogen, alkyl, alkenyl, aryl, arylalkyl, hydroxyalkyl, halogenalkyl, alkoxy, COR10, CONR10R11, OR10, S(O)mR10, NR10COR11 or NR10R11, where R10 is hydrogen, alkyl, alkenyl, aryl, arylalkyl, hydroxyalkyl, halogenalkyl, alkoxy or hydroxy and R11 is hydrogen, alkyl, aryl, arylalkyl, alkoxy, aryloxy, hydroxy or acyl, or in case where X is NR11, R1 can also be carboxylalkyl; R6 is hydrogen, alkyl, alkenyl, aryl, arylalkyl; R2 and R7 mean hydrogen, alkyl, aryl, arylalkyl, alkenyl, COR10, CONR10R11, halogen, trifluoromethyl, nitro or cyano, where R10 and R11 are defined as above; R3 is hydrogen, alkyl, aryl or arylalkyl; A means alkyl or substituted alkyl, m is 0-2 and n is 1-3; Y means O, NR11 or S, where R11 is the same as above; X means O, NR11 or S, where R11 is the same as above, R4, R5, R8 and R9 mean independently one of the following groups (a), (b), (c), (d), (e), (f), (g), or in case where X is NR11, R4, R5, R8 and R9 can also independently mean HOOC-, R12OOC-, H2NCO- or HOHNCO-, wherein R12 means alkyl, arylalkyl or aryl, and wherein each aryl residue defined above by itself or as part of another group may be substituted, and pharmaceutically acceptable salts and esters thereof. The compounds have phospholamban inhibiting activity and are useful for treating heart failure.

IPC 1-7 (main, further and additional classification)

C07D 407/14; A61K 31/37; A61K 31/41; A61K 31/47; C07D 215/20; C07D 401/14; C07D 413/14

IPC 8 full level (invention and additional information)

C07D 215/22 (2006.01); A61K 31/37 (2006.01); A61K 31/41 (2006.01); A61K 31/4704 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61P 9/00 (2006.01); A61P 9/04 (2006.01); A61P 43/00 (2006.01); C07D 215/227 (2006.01); C07D 311/16 (2006.01); C07D 311/58 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01)

CPC (invention and additional information)

C07D 215/227 (2013.01); C07D 311/16 (2013.01); C07D 311/58 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01)

Citation (search report)

See references of WO 9915523A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9915523 A1 19990401; AU 735729 B2 20010712; AU 9350898 A 19990412; BR 9813216 A 20000829; CA 2304849 A1 19990401; CN 1143857 C 20040331; CN 1271357 A 20001025; EA 003084 B1 20021226; EE 04494 B1 20050615; EE 200000179 A 20010416; EP 1017691 A1 20000712; HU 0003647 A2 20010828; HU 0003647 A3 20021228; ID 24373 A 20000713; IL 134662 D0 20010430; JP 2003525838 A 20030902; NO 20001569 A 20000324; NO 20001569 D0 20000324; NZ 503044 A 20010831; PL 339493 A1 20001218; SK 3902000 A3 20001211; TR 200000764 T2 20010321

INPADOC legal status

2006-09-27 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20060401

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000316

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: LT PAYMENT 20000316;LV PAYMENT 20000316;MK PAYMENT 20000316;RO PAYMENT 20000316;SI PAYMENT 20000316