EP 1017691 A1 20000712 - BISETHERS OF 1-OXA, AZA AND THIANAPHTHALEN-2-ONES AS PHOSPHOLAMBAN INHIBITORS
Title (en)
BISETHERS OF 1-OXA, AZA AND THIANAPHTHALEN-2-ONES AS PHOSPHOLAMBAN INHIBITORS
Title (de)
DIETHER VON 1-OXA-, AZA- UND THIANAPHTHALIN-2-ONEN ALS PHOSPHOLAMBANHEMMER
Title (fr)
BISETHERS DE 1-OXA, AZA ET THIANAPHTALENE-2-ONE INHIBITEURS DU PHOSPHOLAMBANE
Publication
Application
Priority
- FI 9800755 W 19980924
- US 93711997 A 19970924
- US 99015097 A 19971212
- US 10411498 A 19980625
Abstract (en)
[origin: WO9915523A1] Therapeutically active compounds of formula (I) or (II), in which R1 is hydrogen, alkyl, alkenyl, aryl, arylalkyl, hydroxyalkyl, halogenalkyl, alkoxy, COR10, CONR10R11, OR10, S(O)mR10, NR10COR11 or NR10R11, where R10 is hydrogen, alkyl, alkenyl, aryl, arylalkyl, hydroxyalkyl, halogenalkyl, alkoxy or hydroxy and R11 is hydrogen, alkyl, aryl, arylalkyl, alkoxy, aryloxy, hydroxy or acyl, or in case where X is NR11, R1 can also be carboxylalkyl; R6 is hydrogen, alkyl, alkenyl, aryl, arylalkyl; R2 and R7 mean hydrogen, alkyl, aryl, arylalkyl, alkenyl, COR10, CONR10R11, halogen, trifluoromethyl, nitro or cyano, where R10 and R11 are defined as above; R3 is hydrogen, alkyl, aryl or arylalkyl; A means alkyl or substituted alkyl, m is 0-2 and n is 1-3; Y means O, NR11 or S, where R11 is the same as above; X means O, NR11 or S, where R11 is the same as above, R4, R5, R8 and R9 mean independently one of the following groups (a), (b), (c), (d), (e), (f), (g), or in case where X is NR11, R4, R5, R8 and R9 can also independently mean HOOC-, R12OOC-, H2NCO- or HOHNCO-, wherein R12 means alkyl, arylalkyl or aryl, and wherein each aryl residue defined above by itself or as part of another group may be substituted, and pharmaceutically acceptable salts and esters thereof. The compounds have phospholamban inhibiting activity and are useful for treating heart failure.
IPC 1-7
C07D 407/14; C07D 413/14; C07D 401/14; C07D 215/20; A61K 31/37; A61K 31/47; A61K 31/41
IPC 8 full level
A61K 31/37 (2006.01); A61K 31/41 (2006.01); A61K 31/4704 (2006.01); A61K 31/4709 (2006.01); A61K 31/497 (2006.01); A61P 9/00 (2006.01); A61P 9/04 (2006.01); C07D 215/22 (2006.01); A61P 43/00 (2006.01); C07D 215/227 (2006.01); C07D 311/16 (2006.01); C07D 311/58 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 405/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01)
CPC (source: EP KR)
A61P 9/00 (2018.01 - EP); A61P 9/04 (2018.01 - EP); A61P 9/10 (2018.01 - EP); A61P 43/00 (2018.01 - EP); C07D 215/227 (2013.01 - EP KR); C07D 311/16 (2013.01 - EP KR); C07D 311/58 (2013.01 - EP KR); C07D 401/14 (2013.01 - EP KR); C07D 405/14 (2013.01 - EP KR); C07D 413/14 (2013.01 - EP KR)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9915523 A1 19990401; AU 735729 B2 20010712; AU 9350898 A 19990412; BR 9813216 A 20000829; CA 2304849 A1 19990401; CN 1143857 C 20040331; CN 1271357 A 20001025; EA 003084 B1 20021226; EA 200000352 A1 20001030; EE 04494 B1 20050615; EE 200000179 A 20010416; EP 1017691 A1 20000712; HU P0003647 A2 20010828; HU P0003647 A3 20021228; ID 24373 A 20000713; IL 134662 A0 20010430; JP 2003525838 A 20030902; KR 20010015607 A 20010226; NO 20001569 D0 20000324; NO 20001569 L 20000324; NZ 503044 A 20010831; PL 339493 A1 20001218; SK 3902000 A3 20001211; TR 200000764 T2 20010321
DOCDB simple family (application)
FI 9800755 W 19980924; AU 9350898 A 19980924; BR 9813216 A 19980924; CA 2304849 A 19980924; CN 98809438 A 19980924; EA 200000352 A 19980924; EE P200000179 A 19980924; EP 98946482 A 19980924; HU P0003647 A 19980924; ID 20000564 A 19980924; IL 13466298 A 19980924; JP 2000512828 A 19980924; KR 20007003094 A 20000323; NO 20001569 A 20000324; NZ 50304498 A 19980924; PL 33949398 A 19980924; SK 3902000 A 19980924; TR 200000764 T 19980924