Global patent index - EP 1017695 A1

EP 1017695 A1 2000-07-12 - RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (en)

RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (de)

TRENNUNG VON OPTISCH AKTIVEN VERBINDUNGEN

Title (fr)

RESOLUTION DE COMPOSES OPTIQUEMENT ACTIFS

Publication

EP 1017695 A1 (EN)

Application

EP 98946144 A

Priority

  • AU 9800807 W
  • AU PO944597 A
  • AU PP071397 A
  • AU PP146898 A

Abstract (en)

[origin: WO9916769A1] Methods for the separation of enantiomers of mianserin or mianserin-like compounds by using (+)- or (-)-di-p-toluoyl-(L) or (D)-tartaric acid. Also claimed are optically pure (+)- or (-)- mianserin-like compounds and pharmaceutical preparations containing these compounds. Additionally methods for treating disturbances of 5-hydroxytrytamine metabolism and histamine metabolism, and treating conditions such as depression, hypertension, congestive heart failure, migraine, anxiety, schizophrenia, gastrointestinal disturbances, diarrhoea, asthma or allergic conditions is also claimed. The mianserin-like compound has formula (1) wherein X = CH2, O, S or NR<4>, and Y = H, CN or (2); Z = O, S or NR<2>.

IPC 1-7 (main, further and additional classification)

C07D 487/04; A61K 31/55; C07D 498/04; C07D 513/04

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)

CPC (invention and additional information)

C07D 487/04 (2013.01); C07D 513/04 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9916769 A1 19990408; EP 1017695 A1 20000712; EP 1017695 A4 20020116

INPADOC legal status

2002-03-06 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Date of withdrawal: 20020109

2002-01-16 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20011203

2002-01-16 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000323

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE