Global Patent Index - EP 1017695 A1

EP 1017695 A1 2000-07-12 - RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (en)

RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (de)

TRENNUNG VON OPTISCH AKTIVEN VERBINDUNGEN

Title (fr)

RESOLUTION DE COMPOSES OPTIQUEMENT ACTIFS

Publication

EP 1017695 A1 (EN)

Application

EP 98946144 A

Priority

  • AU 9800807 W
  • AU PO944597 A
  • AU PP071397 A
  • AU PP146898 A

Abstract (en)

[origin: WO9916769A1] Methods for the separation of enantiomers of mianserin or mianserin-like compounds by using (+)- or (-)-di-p-toluoyl-(L) or (D)-tartaric acid. Also claimed are optically pure (+)- or (-)- mianserin-like compounds and pharmaceutical preparations containing these compounds. Additionally methods for treating disturbances of 5-hydroxytrytamine metabolism and histamine metabolism, and treating conditions such as depression, hypertension, congestive heart failure, migraine, anxiety, schizophrenia, gastrointestinal disturbances, diarrhoea, asthma or allergic conditions is also claimed. The mianserin-like compound has formula (1) wherein X = CH2, O, S or NR<4>, and Y = H, CN or (2); Z = O, S or NR<2>.

IPC 1-7 (main, further and additional classification)

C07D 487/04; A61K 31/55; C07D 498/04; C07D 513/04

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)

CPC (invention and additional information)

C07D 487/04 (2013.01); C07D 513/04 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9916769 A1 19990408; EP 1017695 A1 20000712; EP 1017695 A4 20020116