Global Patent Index - EP 1017695 A4

EP 1017695 A4 20020116 - RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (en)

RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (de)

TRENNUNG VON OPTISCH AKTIVEN VERBINDUNGEN

Title (fr)

RESOLUTION DE COMPOSES OPTIQUEMENT ACTIFS

Publication

EP 1017695 A4 20020116 (EN)

Application

EP 98946144 A 19980925

Priority

  • AU 9800807 W 19980925
  • AU PO944597 A 19970926
  • AU PP071397 A 19971203
  • AU PP146898 A 19980123

Abstract (en)

[origin: WO9916769A1] Methods for the separation of enantiomers of mianserin or mianserin-like compounds by using (+)- or (-)-di-p-toluoyl-(L) or (D)-tartaric acid. Also claimed are optically pure (+)- or (-)- mianserin-like compounds and pharmaceutical preparations containing these compounds. Additionally methods for treating disturbances of 5-hydroxytrytamine metabolism and histamine metabolism, and treating conditions such as depression, hypertension, congestive heart failure, migraine, anxiety, schizophrenia, gastrointestinal disturbances, diarrhoea, asthma or allergic conditions is also claimed. The mianserin-like compound has formula (1) wherein X = CH2, O, S or NR<4>, and Y = H, CN or (2); Z = O, S or NR<2>.

IPC 1-7

C07D 487/04; C07D 498/04; C07D 513/04; A61K 31/55

IPC 8 full level

C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)

CPC (source: EP)

C07D 487/04 (2013.01); C07D 513/04 (2013.01)

Citation (search report)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9916769 A1 19990408; EP 1017695 A1 20000712; EP 1017695 A4 20020116

DOCDB simple family (application)

AU 9800807 W 19980925; EP 98946144 A 19980925