EP 1017695 A4 20020116 - RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (en)

RESOLUTION OF OPTICALLY-ACTIVE COMPOUNDS

Title (de)

TRENNUNG VON OPTISCH AKTIVEN VERBINDUNGEN

Title (fr)

RESOLUTION DE COMPOSES OPTIQUEMENT ACTIFS

Publication

EP 1017695 A4 20020116 (EN)

Application

EP 98946144 A 19980925

Priority

AU 9800807 W 19980925
AU PO944597 A 19970926
AU PP071397 A 19971203
AU PP146898 A 19980123

Abstract (en)

[origin: WO9916769A1] Methods for the separation of enantiomers of mianserin or mianserin-like compounds by using (+)- or (-)-di-p-toluoyl-(L) or (D)-tartaric acid. Also claimed are optically pure (+)- or (-)- mianserin-like compounds and pharmaceutical preparations containing these compounds. Additionally methods for treating disturbances of 5-hydroxytrytamine metabolism and histamine metabolism, and treating conditions such as depression, hypertension, congestive heart failure, migraine, anxiety, schizophrenia, gastrointestinal disturbances, diarrhoea, asthma or allergic conditions is also claimed. The mianserin-like compound has formula (1) wherein X = CH2, O, S or NR<4>, and Y = H, CN or (2); Z = O, S or NR<2>.

IPC 1-7

C07D 487/04; C07D 498/04; C07D 513/04; A61K 31/55

IPC 8 full level

C07D 487/04 (2006.01); C07D 498/04 (2006.01); C07D 513/04 (2006.01)

CPC (source: EP)

C07D 487/04 (2013.01); C07D 513/04 (2013.01)

Citation (search report)

[DX] US 3701778 A 19721031 - BURG WILLEM JACOB VAN DER
[X] EP 0126243 A1 19841128 - ANT NACHRICHTENTECH [DE]
[X] CH 573925 A5 19760331 - AKZO NV
[X] US 3534041 A 19701013 - BURG WILLEM JACOB VAN DER, et al
[X] US 5049637 A 19910917 - COPP FREDERICK C [GB], et al
[X] EP 0421823 A2 19910410 - SANKYO CO [JP]
[X] US 4025513 A 19770524 - OLIVIE JACQUES
[X] PATENT ABSTRACTS OF JAPAN vol. 017, no. 627 (C - 1131) 19 November 1993 (1993-11-19)
[X] PATENT ABSTRACTS OF JAPAN vol. 018, no. 485 (C - 1248) 9 September 1994 (1994-09-09)
[X] PATENT ABSTRACTS OF JAPAN vol. 1996, no. 01 31 January 1996 (1996-01-31)
[X] JACKSON W R ET AL: "CHEMICAL DESIGN OF PERIPHERALLY ACTING COMPOUNDS", CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, XX, XX, vol. 19, no. 1, 1992, pages 17 - 23, XP000650436
See references of WO 9916769A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9916769 A1 19990408; EP 1017695 A1 20000712; EP 1017695 A4 20020116

DOCDB simple family (application)

AU 9800807 W 19980925; EP 98946144 A 19980925