EP 1017698 A1 20000712 - PROCESS FOR RECOVERY OF A (beta)-LACTAM ANTIBIOTIC
Title (en)
PROCESS FOR RECOVERY OF A (beta)-LACTAM ANTIBIOTIC
Title (de)
VERFAHREN ZUR GEWINNUNG VON EINEM BETA-LAKTAM ANTIBIOTIKUM
Title (fr)
METHODE DE RECUPERATION D'UN BETA-LACTAMINE ANTIBIOTIQUE
Publication
Application
Priority
- NL 9800538 W 19980918
- NL 1007077 A 19970919
Abstract (en)
[origin: WO9915531A1] Process for recovery of a beta -lactam antibiotic from a mixture containing beta -lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between (3) and (8) at a concentration such that FG remains in solution, the solid beta -lactam antibiotic obtained being recovered and the remaining liquid being subjected to a concentrating step in which a slurry with solid beta -lactam antibiotic and solid FG develops, the slurry is brought to a pH at which the beta -lactam antibiotic dissolves, FG is separated as a solid and the beta -lactam antibiotic present in the mother liquor is at least partially utilized. Preferably, use is made of an initial mixture substantially contaiing beta -lactam antibiotic and FG originating from an enzymatic acylation reaction in which the corresponding beta -lactam nucleus, in particular 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-amino-3-chloro-cef-3-em-4-carboxylic acid, is acylated with a D-phenyl glycine derivative.
IPC 1-7
IPC 8 full level
C07D 499/00 (2006.01); C07D 499/18 (2006.01); C07D 501/00 (2006.01); C07D 501/12 (2006.01); C12P 35/04 (2006.01); C12P 37/04 (2006.01)
CPC (source: EP KR)
C07D 499/00 (2013.01 - EP); C07D 499/18 (2013.01 - KR); C07D 501/00 (2013.01 - EP); C07D 501/12 (2013.01 - KR); C12P 35/04 (2013.01 - EP KR); C12P 37/04 (2013.01 - EP KR)
Citation (search report)
See references of WO 9915531A1
Designated contracting state (EPC)
AT ES IT NL
DOCDB simple family (publication)
WO 9915531 A1 19990401; AU 9189798 A 19990412; BR 9812482 A 20000919; CN 1279685 A 20010110; EP 1017698 A1 20000712; IN 188409 B 20020921; KR 20010024028 A 20010326; NL 1007077 C2 19990322; TR 200000880 T2 20001121
DOCDB simple family (application)
NL 9800538 W 19980918; AU 9189798 A 19980918; BR 9812482 A 19980918; CN 98811310 A 19980918; EP 98944337 A 19980918; IN 2016MA1998 A 19980908; KR 20007002763 A 20000316; NL 1007077 A 19970919; TR 200000880 T 19980918