EP 1017699 A1 20000712 - PROCESS FOR RECOVERY OF A $g(b)-LACTAM ANTIBIOTIC
Title (en)
PROCESS FOR RECOVERY OF A $g(b)-LACTAM ANTIBIOTIC
Title (de)
VERFAHREN ZUR GEWINNUNG VON EINEM BETA-LAKTAM ANTIBIOTIKUM
Title (fr)
METHODE DE RECUPERATION DE BETA-LACTAMINE
Publication
Application
Priority
- NL 9800539 W 19980918
- NL 1007076 A 19970919
Abstract (en)
[origin: WO9915532A1] Process for recovery of a beta -lactam antibiotic from a mixture containing beta -lactam antibiotic and D-phenyl glycine (FG) in solution, with the mixture being brought to a pH between 3 and 8 at a temperature between -5 and 20 DEG C and at a concentration such that FG remains in solution, the solid beta -lactam antibiotic obtained being recovered and the remaining liquid being subjected to a temperature increase to a temperature between 10 and 60 DEG C, with formation of solid FG, FG being separated out as a solid, and the mother liquor being at least partially recirculated. Use is preferably made of an initial mixture substantially containing beta -lactam antibiotic and FG originating from an enzymatic acylation reaction in which the corresponding beta -lactam nucleus, in particular 6-aminopenicillanic acid, 7-aminodesacetoxycephalosporanic acid and 7-amino-3-chloro-cef-3-em-4-carboxylic acid, is acylated with a D-phenyl glycine derivative.
IPC 1-7
IPC 8 full level
C07D 499/00 (2006.01); C07D 499/18 (2006.01); C07D 501/00 (2006.01); C07D 501/12 (2006.01); C12P 35/04 (2006.01); C12P 37/04 (2006.01)
CPC (source: EP KR)
C07D 499/00 (2013.01 - EP); C07D 499/18 (2013.01 - KR); C07D 501/00 (2013.01 - EP); C07D 501/12 (2013.01 - KR); C12P 35/04 (2013.01 - EP KR); C12P 37/04 (2013.01 - EP KR)
Citation (search report)
See references of WO 9915532A1
Designated contracting state (EPC)
AT ES IT NL
DOCDB simple family (publication)
WO 9915532 A1 19990401; AU 9189898 A 19990412; BR 9812338 A 20000919; CN 1279684 A 20010110; EG 21220 A 20010228; EP 1017699 A1 20000712; IN 187839 B 20020629; KR 20010024027 A 20010326; NL 1007076 C2 19990322; TR 200000881 T2 20010723
DOCDB simple family (application)
NL 9800539 W 19980918; AU 9189898 A 19980918; BR 9812338 A 19980918; CN 98811278 A 19980918; EG 115298 A 19980919; EP 98944338 A 19980918; IN 1757MA1998 A 19980805; KR 20007002762 A 20000316; NL 1007076 A 19970919; TR 200000881 T 19980918