Global Patent Index - EP 1017721 B1

EP 1017721 B1 2009-02-25 - RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T-CELLS

Title (en)

RECOMBINANT MHC MOLECULES USEFUL FOR MANIPULATION OF ANTIGEN-SPECIFIC T-CELLS

Title (de)

REKOMBINANTE MHC-MOLEKÜLE WELCHE NÜTZLICH SIND FÜR DIE MANIPULATION VON ANTIGEN-SPEZIFISCHEN T-ZELLEN

Title (fr)

MOLECULES DE CMH RECOMBINEES UTILES POUR LA MANIPULATION DE CELLULES T SPECIFIQUES A UN ANTIGENE

Publication

EP 1017721 B1 (EN)

Application

EP 98946814 A

Priority

  • US 9818244 W
  • US 6455297 P
  • US 6455597 P

Abstract (en)

[origin: WO9914236A1] Two-domain MHC polypeptides useful for manipulation of antigen-specific T-cells are disclosed. These polypeptides include MHC class II-based molecules that comprise covalently linked beta 1 and alpha 1 domains, and MHC class I-based molecules that comprise covalently linked alpha 1 and alpha 2 domains. These polypeptides may also include covalently linked antigenic determinants, toxic moieties, and/or detectable labels. The disclosed polypeptides can be used to target antigen-specific T-cells, and are useful, among other things, to detect and purify antigen-specific T-cells, to induce or activate T-cells, and to treat conditions mediated by antigen-specific T-cells.

IPC 8 full level (invention and additional information)

C07K 14/52 (2006.01); G01N 33/53 (2006.01); A61K 38/00 (2006.01); A61P 37/02 (2006.01); A61P 37/04 (2006.01); C07K 14/705 (2006.01); C07K 14/74 (2006.01); C07K 17/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12P 21/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/538 (2006.01); G01N 33/543 (2006.01); G01N 33/566 (2006.01); G01N 33/569 (2006.01)

CPC (invention and additional information)

G01N 33/56977 (2013.01); C07K 14/70539 (2013.01); G01N 33/56972 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family

WO 9914236 A1 19990325; AT 423789 T 20090315; AU 741130 B2 20011122; AU 9375098 A 19990405; CA 2302779 A1 19990325; CA 2302779 C 20100202; CY 1110274 T1 20150114; DE 69840600 D1 20090409; DK 1017721 T3 20090420; EP 1017721 A1 20000712; EP 1017721 A4 20030409; EP 1017721 B1 20090225; ES 2323098 T3 20090706; JP 2001516571 A 20011002; JP 4485679 B2 20100623; PT 1017721 E 20090507; US 2002176864 A1 20021128; US 2005074853 A1 20050407; US 2008064859 A1 20080313; US 6270772 B1 20010807; US 6815171 B2 20041109; US 7265218 B2 20070904