Global Patent Index - EP 1017724 A2

EP 1017724 A2 2000-07-12 - IMMUNOLOGICAL METHOD OF IDENTIFYING ANTIGEN-RESPONSIVE T-CELLS

Title (en)

IMMUNOLOGICAL METHOD OF IDENTIFYING ANTIGEN-RESPONSIVE T-CELLS

Title (de)

IMMUNOLOGISCHE VERFAHREN ZUR IDENTIFIZIERUNG VON ANTIGENREAKTIVEN T-ZELLEN

Title (fr)

PROCEDE D'IMMUNOLOGIE POUR L'IDENTIFICATION DE CELLULES T REPONDANT A UN ANTIGEN

Publication

EP 1017724 A2 (EN)

Application

EP 98924427 A

Priority

  • GB 9801382 W
  • GB 9710820 A

Abstract (en)

[origin: WO9854223A2] A method of identifying an antigen-responsive T cell within a population of T cells, the method comprising the steps of: (1) obtaining a sample containing T cells which have responded to the antigen; (2) determining individually for each of a plurality of specific T cell receptors, or individually for each of a plurality of subsets of T cell receptors, whether expression of a gene encoding a specific T cell receptor, or whether expression of genes encoding a subset of T cell receptors, has increased per specific T cell receptor-positive T cell or per specific T cell receptor-positive T cell subset compared to the expression of said gene or genes in a sample containing T cells which have not responded to the antigen. The method is useful for identifying antigen-responsive T cells which are associated with a disease state such as rheumatoid arthritis.

IPC 1-7 (main, further and additional classification)

C07K 14/725

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); C07K 14/725 (2006.01); C12Q 1/06 (2006.01); C12Q 1/68 (2006.01); G01N 33/50 (2006.01)

CPC (invention and additional information)

G01N 33/505 (2013.01); C07K 14/7051 (2013.01); C12Q 1/6881 (2013.01); C12Q 2600/158 (2013.01)

Citation (search report)

See references of WO 9854223A3

Designated contracting state (EPC)

CH DE FR GB IT LI NL SE

EPO simple patent family

WO 9854223 A2 19981203; WO 9854223 A3 19990304; AU 728909 B2 20010118; AU 7663198 A 19981230; CA 2291004 A1 19981203; EP 1017724 A2 20000712; GB 9710820 D0 19970723; JP 2001517958 A 20011009

INPADOC legal status


2004-07-14 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20031230

2003-07-16 [RTI1] TITLE (CORRECTION)

- Free text: IMMUNOLOGICAL METHOD OF IDENTIFYING ANTIGEN-RESPONSIVE T-CELLS

2003-03-05 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030120

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991115

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): CH DE FR GB IT LI NL SE