EP 1017724 A2 20000712 - IMMUNOLOGICAL METHOD OF IDENTIFYING ANTIGEN-RESPONSIVE T-CELLS
Title (en)
IMMUNOLOGICAL METHOD OF IDENTIFYING ANTIGEN-RESPONSIVE T-CELLS
Title (de)
IMMUNOLOGISCHE VERFAHREN ZUR IDENTIFIZIERUNG VON ANTIGENREAKTIVEN T-ZELLEN
Title (fr)
PROCEDE D'IMMUNOLOGIE POUR L'IDENTIFICATION DE CELLULES T REPONDANT A UN ANTIGEN
Publication
Application
Priority
- GB 9801382 W 19980527
- GB 9710820 A 19970527
Abstract (en)
[origin: WO9854223A2] A method of identifying an antigen-responsive T cell within a population of T cells, the method comprising the steps of: (1) obtaining a sample containing T cells which have responded to the antigen; (2) determining individually for each of a plurality of specific T cell receptors, or individually for each of a plurality of subsets of T cell receptors, whether expression of a gene encoding a specific T cell receptor, or whether expression of genes encoding a subset of T cell receptors, has increased per specific T cell receptor-positive T cell or per specific T cell receptor-positive T cell subset compared to the expression of said gene or genes in a sample containing T cells which have not responded to the antigen. The method is useful for identifying antigen-responsive T cells which are associated with a disease state such as rheumatoid arthritis.
IPC 1-7
IPC 8 full level
C07K 14/725 (2006.01); C12N 15/09 (2006.01); C12Q 1/06 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6881 (2018.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61P 31/00 (2017.12); A61P 37/00 (2017.12); C07K 14/7051 (2013.01); C12Q 1/6881 (2013.01); G01N 33/505 (2013.01); C12Q 2600/158 (2013.01)
Citation (search report)
See references of WO 9854223A2
Designated contracting state (EPC)
CH DE FR GB IT LI NL SE
DOCDB simple family (publication)
WO 9854223 A2 19981203; WO 9854223 A3 19990304; AU 728909 B2 20010118; AU 7663198 A 19981230; CA 2291004 A1 19981203; EP 1017724 A2 20000712; GB 9710820 D0 19970723; JP 2001517958 A 20011009
DOCDB simple family (application)
GB 9801382 W 19980527; AU 7663198 A 19980527; CA 2291004 A 19980527; EP 98924427 A 19980527; GB 9710820 A 19970527; JP 50035099 A 19980527