Global Patent Index - EP 1017795 A4

EP 1017795 A4 20020508 - DETECTING COW, SHEEP AND PIG PRIONS IN A SAMPLE AND TRANSGENIC ANIMAL USED FOR SAME

Title (en)

DETECTING COW, SHEEP AND PIG PRIONS IN A SAMPLE AND TRANSGENIC ANIMAL USED FOR SAME

Title (de)

DETEKTION VON RINDER-, SCHAF- UND SCHWEINE-PRIONEN IN EINER PROBE UND TRANSGENES TIER, WELCHES DAFÜR GEBRAUCHT WIRD

Title (fr)

DETECTION DES PRIONS DE VACHE, DE MOUTON, ET DE COCHON DANS UN ECHANTILLON, ET ANIMAUX TRANSGENIQUES UTILISES A CETTE FIN

Publication

EP 1017795 A4 20020508 (EN)

Application

EP 98945791 A 19980828

Priority

  • US 9817879 W 19980828
  • US 93536397 A 19970922

Abstract (en)

[origin: WO9915640A1] Transgenic animals are produced which animals have (1) their endogenous PrP gene ablated; and (2) have an exogenous PrP gene from a genetically diverse animal. The transgenic animal is preferably a mouse, rat or hamster with mice being particularly preferred. The exogenous PrP gene is preferably from a sheep, cow, or pig with cow PrP genes being particularly preferred. When a mouse of the invention is inoculated with a sample containing prions which generally only infects a genetically diverse species (e.g. a cow) the mouse will become ill within about 250 days or less. Methods of producing the transgenic animals are disclosed including (1) microinjecting a mouse egg (having an ablated endogenous PrP gene) with a bovine PrP gene, or (2) breeding a mouse with an ablated PrP gene with a mouse with a bovine PrP gene. Mice produced are used to test samples for the presence of prions which generally only infect cows.

IPC 1-7

C12N 15/00

IPC 8 full level

A01K 67/027 (2006.01); C07K 14/47 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

A01K 67/0275 (2013.01); C07K 14/47 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0318 (2013.01); A01K 2267/0337 (2013.01); A01K 2267/0343 (2013.01); G01N 2800/2828 (2013.01)

Citation (search report)

  • [X] US 5565186 A 19961015 - PRUSINER STANLEY B [US], et al
  • [X] WO 9704814 A1 19970213 - UNIV CALIFORNIA [US]
  • [PX] US 5792901 A 19980811 - PRUSINER STANLEY B [US], et al
  • [PX] US 5763740 A 19980609 - PRUSINER STANLEY B [US], et al
  • [X] BUSCHMANN A ET AL: "Generation of transgenic mice expressing the bovine prion protein (PrP).", JOURNAL OF MOLECULAR MEDICINE (BERLIN), vol. 75, no. 7, 1997, XIX Symposium of the International Association for Comparative Research on Leukemia and Related Diseases;Heidelberg, Germany; July 13-18, 1997, pages B176 - B177, XP001061857, ISSN: 0946-2716
  • [PX] SCOTT MICHAEL R ET AL: "Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 94, no. 26, 23 December 1997 (1997-12-23), pages 14279 - 14284, XP002158407, ISSN: 0027-8424
  • [A] TELLING G C ET AL: "INTERACTIONS BETWEEN WILD-TYPE AND MUTANT PRION PROTEINS MODULATE NEURODEGENERATION IN TRANSGENIC MICE", GENES AND DEVELOPMENT, COLD SPRING HARBOR, NY, US, vol. 10, no. 14, 15 July 1996 (1996-07-15), pages 1736 - 1750, XP000675264, ISSN: 0890-9369
  • [A] PRUSINER S B: "Molecular biology and pathogenesis of prion diseases", TIBS TRENDS IN BIOCHEMICAL SCIENCES, ELSEVIER PUBLICATION, CAMBRIDGE, EN, vol. 21, no. 12, 1 December 1996 (1996-12-01), pages 482 - 487, XP004063036, ISSN: 0968-0004
  • [A] GABIZON R ET AL: "Of mice and (mad) cows - transgenic mice help to understand prions", TRENDS IN GENETICS, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 13, no. 7, 1 July 1997 (1997-07-01), pages 264 - 269, XP004081447, ISSN: 0168-9525
  • [T] PRUSINER STANLEY B: "Prions", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 95, no. 23, 10 November 1998 (1998-11-10), pages 13363 - 13383, XP002177728, ISSN: 0027-8424
  • See references of WO 9915640A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9915640 A1 19990401; AU 752933 B2 20021003; AU 9295398 A 19990412; CA 2302836 A1 19990401; EP 1017795 A1 20000712; EP 1017795 A4 20020508; JP 2001517775 A 20011009

DOCDB simple family (application)

US 9817879 W 19980828; AU 9295398 A 19980828; CA 2302836 A 19980828; EP 98945791 A 19980828; JP 2000512933 A 19980828