EP 1017838 A2 20000712 - EXPRESSION OF GENES IN HEMATOPOIETIC STEM CELLS IN HISCHAEMIC CONDITIONS
Title (en)
EXPRESSION OF GENES IN HEMATOPOIETIC STEM CELLS IN HISCHAEMIC CONDITIONS
Title (de)
GENEXPRESSION IN HÄMOTOPOIETISCHEN STAMMZELLEN UNTER HISCHÄMISCHEN BEDINGUNGEN
Title (fr)
METHODE
Publication
Application
Priority
- GB 9802885 W 19980923
- GB 9720216 A 19970923
- GB 9720465 A 19970925
Abstract (en)
[origin: WO9915684A2] A retroviral vector is described. The retroviral vector comprises a functional splice donor site and a functional splice acceptor site; wherein the functional splice donor site and the functional splice acceptor site flank a first nucleotide sequence of interest ("NOI"); wherein the functional splice donor site is upstream of the functional splice acceptor site; wherein the retroviral vector is derived from a retroviral pro-vector; wherein the retroviral pro-vector comprises a first nucleotide sequence ("NS") capable of yielding the functional splice donor site and a second NS capable of yielding the functional splice acceptor site; wherein the first NS is downstream of the second NS; such that the retroviral vector is formed as a result of reverse transcription of the retroviral pro-vector.
[origin: WO9915684A2] A modified haematopoeitic stem cell (MHSC) is described. The MHSC comprises at least one expressable nucleotide sequence of interest (NOI) wherein the or each NOI is operably linked to one or more ischaemia like response element (ILRE).
IPC 1-7
IPC 8 full level
A61K 35/12 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01); C07K 14/145 (2006.01); C07K 14/155 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/09 (2006.01); C12N 15/63 (2006.01); C12N 15/861 (2006.01); C12N 15/867 (2006.01); C12Q 1/02 (2006.01)
CPC (source: EP KR)
A61P 25/00 (2017.12 - EP); A61P 35/00 (2017.12 - EP); C07K 14/005 (2013.01 - EP); C12N 5/0647 (2013.01 - KR); C12N 15/63 (2013.01 - EP KR); C12N 15/86 (2013.01 - EP KR); A61K 48/00 (2013.01 - EP); C12N 2710/10343 (2013.01 - EP); C12N 2740/15022 (2013.01 - EP); C12N 2740/15043 (2013.01 - EP); C12N 2740/15052 (2013.01 - EP); C12N 2760/20122 (2013.01 - EP); C12N 2810/40 (2013.01 - EP); C12N 2810/60 (2013.01 - EP); C12N 2810/6054 (2013.01 - EP); C12N 2830/002 (2013.01 - EP)
Citation (search report)
See references of WO 9915684A2
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9915684 A2 19990401; WO 9915684 A3 19990610; WO 9915684 A8 19990812; WO 9915684 A9 19990916; AU 747609 B2 20020516; AU 9356298 A 19990412; CA 2303663 A1 19990401; CN 1303442 A 20010711; EP 1017838 A2 20000712; GB 0006993 D0 20000510; GB 2345063 A 20000628; GB 2345063 B 20020724; IL 134897 A0 20010520; JP 2001517453 A 20011009; KR 20010052076 A 20010625; NO 20001487 D0 20000322; NO 20001487 L 20000523; NZ 503318 A 20011130
DOCDB simple family (application)
GB 9802885 W 19980923; AU 9356298 A 19980923; CA 2303663 A 19980923; CN 98811427 A 19980923; EP 98946556 A 19980923; GB 0006993 A 19980923; IL 13489798 A 19980923; JP 2000512973 A 19980923; KR 20007003066 A 20000322; NO 20001487 A 20000322; NZ 50331898 A 19980923