Global Patent Index - EP 1017838 A2

EP 1017838 A2 2000-07-12 - EXPRESSION OF GENES IN HEMATOPOIETIC STEM CELLS IN HISCHAEMIC CONDITIONS

Title (en)

EXPRESSION OF GENES IN HEMATOPOIETIC STEM CELLS IN HISCHAEMIC CONDITIONS

Title (de)

GENEXPRESSION IN HÄMOTOPOIETISCHEN STAMMZELLEN UNTER HISCHÄMISCHEN BEDINGUNGEN

Title (fr)

METHODE

Publication

EP 1017838 A2 (EN)

Application

EP 98946556 A

Priority

  • GB 9802885 W
  • GB 9720216 A
  • GB 9720465 A

Abstract (en)

[origin: WO9915684A2] A modified haematopoeitic stem cell (MHSC) is described. The MHSC comprises at least one expressable nucleotide sequence of interest (NOI) wherein the or each NOI is operably linked to one or more ischaemia like response element (ILRE).

[origin: WO9915684A2] A retroviral vector is described. The retroviral vector comprises a functional splice donor site and a functional splice acceptor site; wherein the functional splice donor site and the functional splice acceptor site flank a first nucleotide sequence of interest ("NOI"); wherein the functional splice donor site is upstream of the functional splice acceptor site; wherein the retroviral vector is derived from a retroviral pro-vector; wherein the retroviral pro-vector comprises a first nucleotide sequence ("NS") capable of yielding the functional splice donor site and a second NS capable of yielding the functional splice acceptor site; wherein the first NS is downstream of the second NS; such that the retroviral vector is formed as a result of reverse transcription of the retroviral pro-vector.

IPC 1-7 (main, further and additional classification)

C12N 15/86; A61K 48/00; C12N 5/10; C12N 15/63

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 35/12 (2006.01); A61K 35/76 (2006.01); A61K 48/00 (2006.01); A61P 25/00 (2006.01); A61P 35/00 (2006.01); C07K 14/145 (2006.01); C07K 14/155 (2006.01); C12N 5/10 (2006.01); C12N 7/00 (2006.01); C12N 15/63 (2006.01); C12N 15/861 (2006.01); C12N 15/867 (2006.01); C12Q 1/02 (2006.01)

CPC (invention and additional information)

C12N 15/86 (2013.01); C07K 14/005 (2013.01); C12N 15/63 (2013.01); A61K 48/00 (2013.01); C12N 2710/10343 (2013.01); C12N 2740/15022 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/15052 (2013.01); C12N 2760/20122 (2013.01); C12N 2810/40 (2013.01); C12N 2810/60 (2013.01); C12N 2810/6054 (2013.01); C12N 2830/002 (2013.01)

Citation (search report)

See references of WO 9915684A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9915684 A2 19990401; WO 9915684 A3 19990610; WO 9915684 A8 19990812; WO 9915684 A9 19990916; AU 747609 B2 20020516; AU 9356298 A 19990412; CA 2303663 A1 19990401; CN 1303442 A 20010711; EP 1017838 A2 20000712; GB 0006993 D0 20000510; GB 2345063 A 20000628; GB 2345063 B 20020724; IL 134897 D0 20010520; JP 2001517453 A 20011009; NO 20001487 A 20000523; NO 20001487 D0 20000322; NZ 503318 A 20011130

INPADOC legal status


2004-11-10 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040723

2004-04-28 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20040312

2000-07-12 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000413

2000-07-12 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-12 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000413;LT PAYMENT 20000413;LV PAYMENT 20000413;MK PAYMENT 20000413;RO PAYMENT 20000413;SI PAYMENT 20000413