Global Patent Index - EP 1019081 A2

EP 1019081 A2 2000-07-19 - APOLIPOPROTEIN E/GROWTH FACTOR COMPLEXES AND METHODS OF USE

Title (en)

APOLIPOPROTEIN E/GROWTH FACTOR COMPLEXES AND METHODS OF USE

Title (de)

APOLIPOPROTEIN E/WACHSTUMSFAKTOR KOMPLEXE UND METHODE ZUR ANWENDUNG

Title (fr)

COMPLEXES D'APOLIPOPROTEINE E/FACTEUR DE CROISSANCE ET PROCEDES D'UTILISATION

Publication

EP 1019081 A2 (EN)

Application

EP 98950816 A

Priority

  • US 9820591 W
  • US 6053397 P

Abstract (en)

[origin: WO9916460A2] Provided herein are compositions comprising complexes of apolipoprotein E and nerve growth factor, neurotrophin 4 or UPSILON -interferon. The apolipoprotein E can be any isoform, but is preferably apolipoprotein E3. Also preferred are covalent complexes or apolipoprotein E and nerve growth factor, UPSILON -interferon, or neurotrophin 4. Further provided are methods of enhancing the survival of neural cells by administering a composition comprising a complex of apolipoprotein E and nerve growth factor or neurotrophin 4. Also disclosed are methods of administering compositions comprising complexes of apolipoprotein E and UPSILON -interferon to protect against virus infection, treat diabetes mellitus, treat bone degradation, treat blood trauma, and produce anti-tumor effects. The claimed methods can be carried out both in vitro and in vivo.

IPC 1-7 (main, further and additional classification)

A61K 38/18; A61K 38/21; C12N 5/06

IPC 8 full level (invention and additional information)

C12N 5/06 (2006.01); A61K 38/00 (2006.01); A61K 38/18 (2006.01); A61K 38/21 (2006.01); A61K 38/22 (2006.01); A61K 45/00 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 31/12 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 38/21 (2013.01); A61K 38/185 (2013.01); A61K 38/217 (2013.01)

Combination set (CPC)

  1. A61K 38/185 + A61K 2300/00
  2. A61K 38/217 + A61K 2300/00

Citation (search report)

See references of WO 9916460A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9916460 A2 19990408; WO 9916460 A3 19990617; AU 9676598 A 19990423; CA 2304720 A1 19990408; EP 1019081 A2 20000719; JP 2001518449 A 20011016

INPADOC legal status


2003-08-27 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030222

2002-11-27 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20021011

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000426

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE