Global Patent Index - EP 1019380 A2

EP 1019380 A2 2000-07-19 - TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS

Title (en)

TRICYCLIC 3-OXO-PROPANENITRILE COMPOUNDS

Title (de)

TRICYCLISCHE 3-OXO-PROPANNITRIL-VERBINDUNGEN

Title (fr)

COMPOSES 3-OXO-PROPANENITRILE TRICYCLIQUES

Publication

EP 1019380 A2 (EN)

Application

EP 98956836 A

Priority

  • EP 9806051 W
  • GB 9720899 A

Abstract (en)

[origin: WO9916753A2] Tricyclic 3-oxo-propanenitrile compounds of formula (I), wherein Y represents a nitrogen atom or a CH or N-oxide group; X represents an oxygen atom or NR2 wherein R2 represents C1-C6 alkyl, benzyl, pyridyl or phenyl, the phenyl being unsubstituted or substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, formylamino and C2-C8 alkanoylamino; each of R and R1 is independently hydrogen, halogen, CF3, C1-C6 alkyl, hydroxy, C1-C6 alkoxy, C3-C4 alkenyloxy, nitro, amino, formylamino, C2-C8 alkanoylamino or C2-C8 alkanoyloxy; m is zero or an integer of 1 to 6; Q is C1-C14 alkyl, phenyl or unsaturated pentatomic heteromonocylic ring containing two or three heteroatoms chosen from oxygen, sulphur and nitrogen, wherein the phenyl ring and the heteromonocylic ring are unsubstituted or substituted by one or two substituents chosen independently from halogen, CF3, C1-C6 alkyl, hydroxy, C1-C6 alkoxy, nitro, amino, formylamino, C2-C8 alkanoylamino or C2-C8 alkanoyloxy; and W represents a -CONH- or -SO2- or -CO- group; and pharmaceutically acceptable salt thereof having kynurenine-3-hydroxylase enzyme inhibitor activity are provided.

IPC 1-7 (main, further and additional classification)

C07D 231/56; A61K 31/415; A61K 31/42; A61K 31/47; C07D 261/20; C07D 471/04

IPC 8 full level (invention and additional information)

C07D 231/54 (2006.01); A61K 31/416 (2006.01); A61K 31/423 (2006.01); A61K 31/4738 (2006.01); A61K 31/4745 (2006.01); A61P 9/02 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); A61P 31/18 (2006.01); A61P 43/00 (2006.01); C07D 231/56 (2006.01); C07D 261/20 (2006.01); C07D 471/04 (2006.01); C07D 498/04 (2006.01)

CPC (invention and additional information)

C07D 471/04 (2013.01); C07D 231/56 (2013.01); C07D 261/20 (2013.01)

Citation (search report)

See references of WO 9916753A3

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9916753 A2 19990408; WO 9916753 A3 19990520; AU 1334399 A 19990423; CA 2302025 A1 19990408; EP 1019380 A2 20000719; GB 9720899 D0 19971203; JP 2001518469 A 20011016

INPADOC legal status


2001-05-09 [18W] WITHDRAWN

- Date of withdrawal: 20010223

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000330

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-19 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000330;LT PAYMENT 20000330;LV PAYMENT 20000330;MK PAYMENT 20000330;RO PAYMENT 20000330;SI PAYMENT 20000330