Global Patent Index - EP 1019386 A1

EP 1019386 A1 2000-07-19 - REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS

Title (en)

REVERSE HYDROXAMATE DERIVATIVES AS METALLOPROTEASE INHIBITORS

Title (de)

HYDROXAMATDERIVATE ALS METALLOPROTEASEINHIBITOREN

Title (fr)

DERIVES D'HYDROXAMATE UTILISES COMME INHIBITEURS DE METALLOPROTEASE

Publication

EP 1019386 A1 (EN)

Application

EP 98913575 A

Priority

  • EP 9801015 W
  • US 3911297 P

Abstract (en)

[origin: WO9838179A1] A family of compounds having general structural formula (I) wherein W is a reverse hydroxamic acid group (a); R5 is hydrogen or lower alkyl; R6 is (b); where Z1 is heteroarylene; preferably: R1 is methyl, ethyl, isopropyl, n-propyl or 3,3,3-trifluoro-n-propyl; R2 is isobutyl or sec-butyl; R3 is hydrogen; R4 is tert-butyl, sec-butyl, 1-methoxy-1-ethyl or 2-(2-pyridylcarbonylamino)-1-ethyl; R5 is hydrogen; and R6 is 2-thiazolyl or 2-pyridyl. Such compounds show potent inhibition of MMP's, cell-free TNF convertase enzyme and TNF release from cells, and in some cases inhibit TNF convertase and TNF release from cells in preference to matrix metalloproteases.

IPC 1-7 (main, further and additional classification)

C07D 277/46; A61K 31/425; A61K 31/44; C07D 213/75; C07D 239/42; C07D 285/12; C07D 417/12

IPC 8 full level (invention and additional information)

A61K 31/42 (2006.01); A61K 31/426 (2006.01); A61K 31/433 (2006.01); A61K 31/4402 (2006.01); A61K 31/4535 (2006.01); A61K 31/505 (2006.01); A61P 1/00 (2006.01); A61P 1/02 (2006.01); A61P 3/10 (2006.01); A61P 19/02 (2006.01); A61P 27/02 (2006.01); A61P 29/00 (2006.01); A61P 35/04 (2006.01); A61P 43/00 (2006.01); C07D 213/75 (2006.01); C07D 239/42 (2006.01); C07D 277/20 (2006.01); C07D 277/46 (2006.01); C07D 285/135 (2006.01); C07D 417/12 (2006.01); C07D 285/12 (2006.01)

CPC (invention and additional information)

C07D 213/75 (2013.01); C07D 239/42 (2013.01); C07D 277/46 (2013.01); C07D 285/135 (2013.01); C07D 417/12 (2013.01)

Citation (search report)

See references of WO 9838179A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9838179 A1 19980903; AP 9901631 D0 19990930; AR 013070 A1 20001213; AU 6822398 A 19980918; BR 9807763 A 20000222; CA 2281664 A1 19980903; EP 1019386 A1 20000719; HR P980096 A2 19981231; IS 5159 A 19990820; JP 2001513767 A 20010904; KR 20000075681 A 20001226; NO 994103 A 19991025; NO 994103 D0 19990825; PE 59199 A1 19990624; PL 335378 A1 20000425; TR 9902063 T2 19991221; ZA 9801532 B 19990824

INPADOC legal status


2002-03-20 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010301

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990824

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-19 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 19990824;LT PAYMENT 19990824;LV PAYMENT 19990824;MK PAYMENT 19990824;RO PAYMENT 19990824;SI PAYMENT 19990824