Global Patent Index - EP 1019402 A1

EP 1019402 A1 2000-07-19 - POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE

Title (en)

POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE

Title (de)

POLYMORPHE FORMEN EINER WACHSTUMSHORMONSEKRETION BEFÖRDEREND VERBINDUNG

Title (fr)

FORMES POLYMORPHES D'UN AGENT DE SECRETION D'HORMONE DE CROISSANCE

Publication

EP 1019402 A1 (EN)

Application

EP 96936869 A

Priority

  • GB 9603361 A
  • US 9616955 W
  • US 590095 P

Abstract (en)

[origin: WO9715574A1] This invention is concerned with polymorphic forms of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)-ethyl]-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations. The present invention is also concerned with processes for preparing these polymorphic forms, pharmaceutical formulations comprising these polymorphic forms as active ingredients and the use of the polymorphic form of the compound and their formulations in the treatment of certain disorders.

IPC 1-7 (main, further and additional classification)

C07D 471/10; A61K 31/445

IPC 8 full level (invention and additional information)

A61K 31/438 (2006.01); A61K 31/445 (2006.01); A61P 3/00 (2006.01); A61P 5/00 (2006.01); C07D 471/10 (2006.01); C07K 5/06 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C07D 471/10 (2013.01); C07K 5/06034 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9715574A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9715574 A1 19970501; AU 707946 B2 19990722; AU 7468696 A 19970515; BG 102476 A 19990430; BR 9611229 A 19990525; CN 1067687 C 20010627; CN 1205703 A 19990120; CO 4770956 A1 19990430; CZ 9801280 A3 19980916; EA 000528 B1 19991028; EA 199800335 A1 19981224; EE 9800147 A 19981215; EP 1019402 A1 20000719; HK 1017894 A1 20010928; HU 9902208 A2 19991028; HU 9902208 A3 20010528; IS 4721 A 19980421; JP 3204266 B2 20010904; JP H10512295 A 19981124; MX 9803351 A 19980930; NO 310556 B1 20010723; NO 981867 A 19980629; NO 981867 D0 19980424; NZ 321370 A 19991129; PL 327511 A1 19981221; SK 51398 A3 19981202; TR 9800726 T2 19980821; YU 56696 A 19990927

INPADOC legal status


2003-11-26 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030501

2001-11-28 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20011015

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19980527

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE