EP 1019402 A1 20000719 - POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE
Title (en)
POLYMORPHIC FORMS OF A GROWTH HORMONE SECRETAGOGUE
Title (de)
POLYMORPHE FORMEN EINER WACHSTUMSHORMONSEKRETION BEFÖRDEREND VERBINDUNG
Title (fr)
FORMES POLYMORPHES D'UN AGENT DE SECRETION D'HORMONE DE CROISSANCE
Publication
Application
Priority
- GB 9603361 A 19960216
- US 9616955 W 19961023
- US 590095 P 19951027
Abstract (en)
[origin: WO9715574A1] This invention is concerned with polymorphic forms of the compound N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)ethyl]-2-amino-2-methylpropanamide methanesulfonate which is a growth hormone secretagogue that is useful in food animals to promote their growth thereby rendering the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, and to treat medical conditions which are improved by the anabolic effects of growth hormone. The instant polymorphic forms have advantages over the other known forms of N-[1(R)-[(1,2-dihydro-1-methanesulfonylspiro[3H-indole-3,4'-piperdin]-1'-yl)carbonyl]-2-(phenylmethyloxy)-ethyl]-2-amino-2-methylpropanamide methanesulfonate in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations. The present invention is also concerned with processes for preparing these polymorphic forms, pharmaceutical formulations comprising these polymorphic forms as active ingredients and the use of the polymorphic form of the compound and their formulations in the treatment of certain disorders.
IPC 1-7
IPC 8 full level
A61K 31/435 (2006.01); A61K 31/438 (2006.01); A61K 31/445 (2006.01); A61K 38/05 (2006.01); A61P 3/00 (2006.01); A61P 5/00 (2006.01); C07D 471/10 (2006.01); C07K 5/06 (2006.01); C07K 5/062 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP KR)
A61K 38/00 (2013.01 - KR); A61P 3/00 (2018.01 - EP); A61P 5/00 (2018.01 - EP); C07D 471/10 (2013.01 - EP KR); C07K 5/06034 (2013.01 - EP KR); A61K 38/00 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9715574 A1 19970501; AU 707946 B2 19990722; AU 7468696 A 19970515; BG 102476 A 19990430; BR 9611229 A 19990525; CA 2235371 A1 19970501; CN 1067687 C 20010627; CN 1205703 A 19990120; CO 4770956 A1 19990430; CZ 128098 A3 19980916; EA 000528 B1 19991028; EA 199800335 A1 19981224; EE 9800147 A 19981215; EP 1019402 A1 20000719; HK 1017894 A1 19991203; HU P9902208 A2 19991028; HU P9902208 A3 20010528; IS 4721 A 19980421; JP 3204266 B2 20010904; JP H10512295 A 19981124; KR 19990067098 A 19990816; MX 9803351 A 19980930; NO 310556 B1 20010723; NO 981867 D0 19980424; NO 981867 L 19980629; NZ 321370 A 19991129; PL 327511 A1 19981221; SK 51398 A3 19981202; TR 199800726 T2 19980821; YU 56696 A 19990927
DOCDB simple family (application)
US 9616955 W 19961023; AU 7468696 A 19961023; BG 10247698 A 19980521; BR 9611229 A 19961023; CA 2235371 A 19961023; CN 96199328 A 19961023; CO 96056663 A 19961025; CZ 128098 A 19961023; EA 199800335 A 19961023; EE 9800147 A 19961023; EP 96936869 A 19961023; HK 99102961 A 19990712; HU P9902208 A 19961023; IS 4721 A 19980421; JP 51673797 A 19961023; KR 19980703038 A 19980427; MX 9803351 A 19980427; NO 981867 A 19980424; NZ 32137096 A 19961023; PL 32751196 A 19961023; SK 51398 A 19961023; TR 9800726 T 19961023; YU 56696 A 19961025