EP 1019439 B1 20111116 - SOLUBLE SINGLE-CHAIN T-CELL RECEPTOR PROTEINS
Title (en)
SOLUBLE SINGLE-CHAIN T-CELL RECEPTOR PROTEINS
Title (de)
LÖSLICHE, EINZELKETTIGE PROTEINE DES T-ZELLREZEPTORS
Title (fr)
PROTEINES SOLUBLES DU RECEPTEUR DES LYMPHOCYTES T A CHAINE UNIQUE
Publication
Application
Priority
- US 9820263 W 19980928
- US 94308697 A 19971002
Abstract (en)
[origin: WO9918129A1] The present invention features fully soluble and functional single-chain T-cell receptor proteins. In one aspect, the invention features soluble fusion proteins comprising an immunoglobin light chain constant region or fragment thereof covalently linked to a single-chain T-cell receptor, wherein the single-chain T-cell receptor comprises a V- alpha chain covalently linked to a V- beta chain by a peptide linker sequence. The single-chain T-cell receptor proteins have a variety of uses including use in screens to detect cells expressly desired MHC-peptide complexes.
IPC 8 full level
C07K 14/725 (2006.01); C12N 15/09 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61K 39/395 (2006.01); A61P 43/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 15/00 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01)
CPC (source: EP KR)
A61P 37/00 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/7051 (2013.01 - EP KR); A61K 38/00 (2013.01 - EP); C07K 2319/00 (2013.01 - EP); C07K 2319/30 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9918129 A1 19990415; AT E533784 T1 20111215; AU 742650 B2 20020110; AU 9586998 A 19990427; CA 2305630 A1 19990415; CA 2305630 C 20121106; CN 1217956 C 20050907; CN 1279690 A 20010110; EP 1019439 A1 20000719; EP 1019439 A4 20021106; EP 1019439 B1 20111116; JP 2001519143 A 20011023; KR 100712256 B1 20070427; KR 20010030846 A 20010416
DOCDB simple family (application)
US 9820263 W 19980928; AT 98949572 T 19980928; AU 9586998 A 19980928; CA 2305630 A 19980928; CN 98811223 A 19980928; EP 98949572 A 19980928; JP 2000514936 A 19980928; KR 20007003504 A 20000331