EP 1019495 A1 20000719 - TRANSGENIC MODEL COMPRISING TCR ALPHA AND BETA CHAINS
Title (en)
TRANSGENIC MODEL COMPRISING TCR ALPHA AND BETA CHAINS
Title (de)
TCR ALPHA- UND BETA-KETTEN ENTHALTENDES TRANSGENMODELL
Title (fr)
MODELE TRANSGENIQUE COMPRENANT DES CHAINES TCR ALPHA/BETA
Publication
Application
Priority
- GB 9802965 W 19980930
- GB 9720888 A 19971001
Abstract (en)
[origin: WO9916867A1] The invention provides a genetically modified non-human mammal having a population of CD4 positive T cells specific for one or a limited number of selected antigens, including at least one transplantation antigen capable of rejecting a tissue transplant containing the transplantation antigen and if applicable the other selected antigens. A genetically modified animal according to the invention has T cell receptor genes which encode a T cell receptor specific for the transplantation antigen. The genetically modified mammal is useful in studying immunological tolerance, in particular in the mechanisms of tolerance to and the rejection of tissue grafts, and in pregnancy. The animals are also useful for testing agents for biological activity in promoting or reducing immunological tolerance.
IPC 1-7
IPC 8 full level
A01K 67/027 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A01K 67/0271 (2013.01); A01K 67/0275 (2013.01); A01K 67/0276 (2013.01); C07K 14/7051 (2013.01); C12N 15/8509 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0381 (2013.01)
Citation (search report)
See references of WO 9916867A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9916867 A1 19990408; EP 1019495 A1 20000719; GB 9720888 D0 19971203; JP 2001518291 A 20011016
DOCDB simple family (application)
GB 9802965 W 19980930; EP 98945429 A 19980930; GB 9720888 A 19971001; JP 2000513938 A 19980930