Global Patent Index - EP 1019495 A1

EP 1019495 A1 2000-07-19 - TRANSGENIC MODEL COMPRISING TCR ALPHA AND BETA CHAINS

Title (en)

TRANSGENIC MODEL COMPRISING TCR ALPHA AND BETA CHAINS

Title (de)

TCR ALPHA- UND BETA-KETTEN ENTHALTENDES TRANSGENMODELL

Title (fr)

MODELE TRANSGENIQUE COMPRENANT DES CHAINES TCR ALPHA/BETA

Publication

EP 1019495 A1 (EN)

Application

EP 98945429 A

Priority

  • GB 9802965 W
  • GB 9720888 A

Abstract (en)

[origin: WO9916867A1] The invention provides a genetically modified non-human mammal having a population of CD4 positive T cells specific for one or a limited number of selected antigens, including at least one transplantation antigen capable of rejecting a tissue transplant containing the transplantation antigen and if applicable the other selected antigens. A genetically modified animal according to the invention has T cell receptor genes which encode a T cell receptor specific for the transplantation antigen. The genetically modified mammal is useful in studying immunological tolerance, in particular in the mechanisms of tolerance to and the rejection of tissue grafts, and in pregnancy. The animals are also useful for testing agents for biological activity in promoting or reducing immunological tolerance.

IPC 1-7 (main, further and additional classification)

C12N 15/00; A01K 67/027; C07K 14/705

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (invention and additional information)

C12N 15/8509 (2013.01); A01K 67/0271 (2013.01); A01K 67/0275 (2013.01); A01K 67/0276 (2013.01); C07K 14/7051 (2013.01); A01K 2217/05 (2013.01); A01K 2217/075 (2013.01); A01K 2227/105 (2013.01); A01K 2267/03 (2013.01); A01K 2267/0381 (2013.01)

Citation (search report)

See references of WO 9916867A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9916867 A1 19990408; EP 1019495 A1 20000719; GB 9720888 D0 19971203; JP 2001518291 A 20011016

INPADOC legal status


2005-10-12 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20050401

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: WALDMANN, HERMAN SIR W.DUNN SCHOOL OF PATHOLOGY

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: COBBOLD, STEPHEN P. SIR W.DUNN SCHOOL OF PATHOLOG

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: ZELENIKA, DIANA SIR W. DUNN SCHOOL OF PATHOLOGY

2001-07-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: MELLOR ANDREW

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000403

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE