EP 1019497 A1 20000719 - HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE
Title (en)
HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE
Title (de)
HAMMERHEAD RIBOZYME MIT ERWEITERTE SCHNITTREGEL
Title (fr)
RIBOZYMES EN TETE DE MARTEAU A FONCTION DE CLIVAGE ETENDUE
Publication
Application
Priority
- US 9812663 W 19980617
- US 87864097 A 19970619
Abstract (en)
[origin: WO9858058A1] Disclosed are compositions having an RNA-cleavage activity, as well as their use for cleaving RNA-substrates in vitro and in vivo. The compositions contain an active center, the subnits of which are selected from nucleotides and/or nucleotide analogues, as well as flanking regions contributing to the formation of a specific hybridization with an RNA substrate. Preferred compositions form, in combination with an RNA substrate, a structure resembling a hammerhead structure. The active center of the disclosed compositions is characterized by the presence of I<15.1> which allows cleavage of RNA substrates having C<16.1>.
IPC 1-7
IPC 8 full level
C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61P 43/00 (2006.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
A61P 43/00 (2017.12); C12N 15/113 (2013.01); C12N 15/1131 (2013.01); C12N 15/1136 (2013.01); C12N 15/1138 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01); C12N 2310/317 (2013.01); C12N 2310/3183 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/33 (2013.01)
Citation (search report)
See references of WO 9858058A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9858058 A1 19981223; AU 7976198 A 19990104; CA 2295207 A1 19981223; EP 1019497 A1 20000719; JP 2002510207 A 20020402
DOCDB simple family (application)
US 9812663 W 19980617; AU 7976198 A 19980617; CA 2295207 A 19980617; EP 98930352 A 19980617; JP 50477699 A 19980617