Global Patent Index - EP 1019497 A1

EP 1019497 A1 2000-07-19 - HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE

Title (en)

HAMMERHEAD RIBOZYMES WITH EXTENDED CLEAVAGE RULE

Title (de)

HAMMERHEAD RIBOZYME MIT ERWEITERTE SCHNITTREGEL

Title (fr)

RIBOZYMES EN TETE DE MARTEAU A FONCTION DE CLIVAGE ETENDUE

Publication

EP 1019497 A1 (EN)

Application

EP 98930352 A

Priority

  • US 9812663 W
  • US 87864097 A

Abstract (en)

[origin: WO9858058A1] Disclosed are compositions having an RNA-cleavage activity, as well as their use for cleaving RNA-substrates in vitro and in vivo. The compositions contain an active center, the subnits of which are selected from nucleotides and/or nucleotide analogues, as well as flanking regions contributing to the formation of a specific hybridization with an RNA substrate. Preferred compositions form, in combination with an RNA substrate, a structure resembling a hammerhead structure. The active center of the disclosed compositions is characterized by the presence of I<15.1> which allows cleavage of RNA substrates having C<16.1>.

IPC 1-7 (main, further and additional classification)

C12N 15/11; A61K 31/70; C07H 21/00; C12N 9/00

IPC 8 full level (invention and additional information)

C12N 15/09 (2006.01); A61K 31/7088 (2006.01); A61P 43/00 (2006.01); C12N 9/22 (2006.01); C12N 15/113 (2010.01); C12Q 1/68 (2006.01); A61K 38/00 (2006.01)

CPC (invention and additional information)

C12N 15/113 (2013.01); C12N 15/1131 (2013.01); C12N 15/1136 (2013.01); C12N 15/1138 (2013.01); A61K 38/00 (2013.01); C12N 2310/111 (2013.01); C12N 2310/121 (2013.01); C12N 2310/317 (2013.01); C12N 2310/3183 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/33 (2013.01)

Combination set (CPC)

  1. C12N 2310/321 + C12N 2310/3523
  2. C12N 2310/321 + C12N 2310/3521

Citation (search report)

See references of WO 9858058A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9858058 A1 19981223; AU 7976198 A 19990104; CA 2295207 A1 19981223; EP 1019497 A1 20000719; JP 2002510207 A 20020402

INPADOC legal status


2004-03-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030903

2003-06-04 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030422

2001-04-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: LUDWIG, JANOS

2001-04-25 [RIN1] INVENTOR (CORRECTION)

- Inventor name: SPROAT, BRIAN, S.

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19991220

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE