Global patent index - EP 1019529 A1

EP 1019529 A1 2000-07-19 - A METHOD OF TREATING CANCER

Title (en)

A METHOD OF TREATING CANCER

Title (de)

VERFAHREN ZUR KREBSBEHANDLUNG

Title (fr)

PROCEDE POUR LE TRAITEMENT DU CANCER

Publication

EP 1019529 A1 (EN)

Application

EP 98941069 A

Priority

  • GB 9724299 A
  • US 9817699 W
  • US 5710297 P

Abstract (en)

[origin: WO9910525A1] The instant invention provides for a method of inhibiting prenyl-protein transferases and treating cancer which comprises administering to a mammal a prenyl-protein transferase inhibitor which is an inhibitor of cellular processing of the H-Ras and K4B-Ras proteins. The invention in particular provides for a method of inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I by administering a compound that is a dual inhibitor of both of those prenyl-protein transferases. The instant invention als provides for a method of identifying such a compound, the method comprising an assay whose readout is a consequence of the biological activity or inhibition of that activity of the Ras protein, thus providing convenient identification of compounds that inhibit cellular processing of the H-Ras and K4B-Ras proteins.

IPC 1-7 (main, further and additional classification)

C12Q 1/48; A01N 43/00; A01N 43/40; A01N 43/50; A61K 31/415; A61K 31/445; A61K 31/55; C12N 9/10

IPC 8 full level (invention and additional information)

A61K 31/00 (2006.01); A61K 31/4178 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/5513 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 233/64 (2006.01); C07D 233/90 (2006.01); C07D 241/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C12N 9/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (invention and additional information)

A61K 31/00 (2013.01); C12Q 1/48 (2013.01); G01N 33/5011 (2013.01)

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9910525 A1 19990304; AU 8921398 A 19990316; CA 2301880 A1 19990304; EP 1019529 A1 20000719; EP 1019529 A4 20020911; JP 2001514191 A 20010911

INPADOC legal status

2004-01-07 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030527

2003-03-05 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20030115

2002-09-11 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20020731

2002-09-11 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000327

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-07-19 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000327;LT PAYMENT 20000327;LV PAYMENT 20000327;MK PAYMENT 20000327;RO PAYMENT 20000327;SI PAYMENT 20000327