EP 1019529 A4 20020911 - A METHOD OF TREATING CANCER

Title (en)

A METHOD OF TREATING CANCER

Title (de)

VERFAHREN ZUR KREBSBEHANDLUNG

Title (fr)

PROCEDE POUR LE TRAITEMENT DU CANCER

Publication

EP 1019529 A4 20020911 (EN)

Application

EP 98941069 A 19980826

Priority

GB 9724299 A 19971118
US 9817699 W 19980826
US 5710297 P 19970827

Abstract (en)

[origin: WO9910525A1] The instant invention provides for a method of inhibiting prenyl-protein transferases and treating cancer which comprises administering to a mammal a prenyl-protein transferase inhibitor which is an inhibitor of cellular processing of the H-Ras and K4B-Ras proteins. The invention in particular provides for a method of inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I by administering a compound that is a dual inhibitor of both of those prenyl-protein transferases. The instant invention als provides for a method of identifying such a compound, the method comprising an assay whose readout is a consequence of the biological activity or inhibition of that activity of the Ras protein, thus providing convenient identification of compounds that inhibit cellular processing of the H-Ras and K4B-Ras proteins.

IPC 1-7

C12Q 1/48; C12N 9/10; A01N 43/00; A01N 43/40; A01N 43/50; A61K 31/55; A61K 31/415; A61K 31/445

IPC 8 full level

A61K 31/00 (2006.01); A61K 31/4178 (2006.01); A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61K 31/445 (2006.01); A61K 31/454 (2006.01); A61K 31/495 (2006.01); A61K 31/496 (2006.01); A61K 31/5513 (2006.01); A61K 38/00 (2006.01); A61K 45/00 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 233/64 (2006.01); C07D 233/90 (2006.01); C07D 241/04 (2006.01); C07D 401/06 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/14 (2006.01); C12N 9/10 (2006.01); C12N 15/09 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01)

CPC (source: EP)

A61K 31/00 (2013.01); A61P 35/00 (2017.12); A61P 43/00 (2017.12); C12Q 1/48 (2013.01); G01N 33/5011 (2013.01)

Citation (search report)

[PX] WO 9730992 A1 19970828 - BRISTOL MYERS SQUIBB CO [US]
[X] WO 9634113 A2 19961031 - UNIV TEXAS [US]
[X] WO 9630343 A1 19961003 - MERCK & CO INC [US], et al
[PX] WO 9738664 A2 19971023 - MERCK & CO INC [US], et al
See references of WO 9910525A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

DOCDB simple family (publication)

WO 9910525 A1 19990304; AU 8921398 A 19990316; CA 2301880 A1 19990304; EP 1019529 A1 20000719; EP 1019529 A4 20020911; JP 2001514191 A 20010911

DOCDB simple family (application)

US 9817699 W 19980826; AU 8921398 A 19980826; CA 2301880 A 19980826; EP 98941069 A 19980826; JP 2000507833 A 19980826