Global Patent Index - EP 1019530 A1

EP 1019530 A1 2000-07-19 - A METHOD OF TREATING CANCER

Title (en)

A METHOD OF TREATING CANCER

Title (de)

VERFAHREN ZUR KREBSBEHANDLUNG

Title (fr)

PROCEDE POUR LE TRAITEMENT DU CANCER

Publication

EP 1019530 A1 (EN)

Application

EP 98944538 A

Priority

  • GB 9807361 A
  • US 9817698 W
  • US 5722897 P

Abstract (en)

[origin: WO9910524A1] The instant invention provides for a method of inhibiting prenyl-protein transferases and treating cancer which comprises administering to a mammal a prenyl-protein transferase inhibitor which is an inhibitor of cellular processing of the H-Ras and K4B-Ras proteins. The invention also provides for a method of inhibiting farnesyl-protein transferase and geranylgeranyl-protein transferase type I by administering a compound that is a dual inhibitor of both of those prenyl-protein transferases. A method of identifying a prenyl-protein transferase inhibitor which is an inhibit or of in vivo growth of cancer cells is also disclosed. The instant method comprises a cell-based in vitro assay which determines the physical state of a protein substrate of geranylgeranyl-protein transferase type I.

IPC 1-7 (main, further and additional classification)

C12Q 1/48; A01N 43/00; A01N 43/40; A01N 43/50; A61K 31/415; A61K 31/445; A61K 31/55; C12N 9/10

IPC 8 full level (invention and additional information)

A01N 43/00 (2006.01); A01N 43/40 (2006.01); A01N 43/50 (2006.01); A61K 31/4178 (2006.01); A61K 31/4427 (2006.01); A61K 31/443 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/496 (2006.01); A61K 31/5513 (2006.01); A61P 35/00 (2006.01); A61P 43/00 (2006.01); C07D 233/64 (2006.01); C07D 233/90 (2006.01); C07D 241/04 (2006.01); C07D 401/12 (2006.01); C07D 403/06 (2006.01); C07D 403/12 (2006.01); C07D 405/04 (2006.01); C12N 9/10 (2006.01); C12Q 1/48 (2006.01)

CPC (invention and additional information)

C12N 9/10 (2013.01)

Citation (search report)

See references of WO 9910524A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9910524 A1 19990304; AU 9205998 A 19990316; CA 2301857 A1 19990304; EP 1019530 A1 20000719; JP 2001514011 A 20010911

INPADOC legal status


2002-11-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020301

2000-07-19 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000327

2000-07-19 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-07-19 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: AL PAYMENT 20000327;LT PAYMENT 20000327;LV PAYMENT 20000327;MK PAYMENT 20000327;RO PAYMENT 20000327;SI PAYMENT 20000327