EP 1021445 A1 20000726 - CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
Title (en)
CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT
Title (de)
ANTIBAKTERIELLE CARBAPENEM-VERBINDUNGEN, ZUBEREITUNGEN DIE SOLCHE VERBINDUNGEN ENTHALTEN UND BEHANDLUNGSVERFAHREN
Title (fr)
COMPOSITIONS ANTIBACTERIENNES DE CARBAPENEM, PREPARATIONS LES CONTENANT ET METHODES DE TRAITEMENT
Publication
Application
Priority
- GB 9624277 A 19961122
- US 9715831 W 19970908
- US 2618496 P 19960912
Abstract (en)
[origin: WO9811108A1] The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a sulfonamide containing ring system linked to the carbapenem nucleus through a CH2 group. The compounds are represented by formula (I) including pharmaceutically acceptable salts thereof, wherein: R<1> represents H or methyl; CO2M represents a carboxylic acid, a carboxylate anion, a pharmaceutically acceptable ester group or a carboxylic acid protected by a protecting group; P represents hydrogen, hydroxyl, F or hydroxyl protected by a hydroxyl-protecting group; X<1> and X<2> represent hydrogen or X<1> and X<2> taken together represent a carbonyl group; and one of AB, BC and CD represents a fused aryl, heteroaryl or heteroarylium ring, and the other variables represent R, said fused aryl, heteroaryl or heteroarylium ring being substituted with from 1-4 R groups. Pharmaceutical compositions and methods of use are also included.
IPC 1-7
IPC 8 full level
C07D 487/04 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/4995 (2006.01); A61P 31/04 (2006.01); C07D 477/14 (2006.01); C07D 519/00 (2006.01)
CPC (source: EP)
A61P 31/04 (2017.12); C07D 477/14 (2013.01); Y02P 20/55 (2015.11)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9811108 A1 19980319; AU 4184497 A 19980402; CA 2264147 A1 19980319; EP 1021445 A1 20000726; EP 1021445 A4 20010207; JP 2001500862 A 20010123
DOCDB simple family (application)
US 9715831 W 19970908; AU 4184497 A 19970908; CA 2264147 A 19970908; EP 97939843 A 19970908; JP 51374698 A 19970908