Global patent index - EP 1021445 A1

EP 1021445 A1 2000-07-26 - CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

Title (en)

CARBAPENEM ANTIBACTERIAL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT

Title (de)

ANTIBAKTERIELLE CARBAPENEM-VERBINDUNGEN, ZUBEREITUNGEN DIE SOLCHE VERBINDUNGEN ENTHALTEN UND BEHANDLUNGSVERFAHREN

Title (fr)

COMPOSITIONS ANTIBACTERIENNES DE CARBAPENEM, PREPARATIONS LES CONTENANT ET METHODES DE TRAITEMENT

Publication

EP 1021445 A1 (EN)

Application

EP 97939843 A

Priority

  • GB 9624277 A
  • US 9715831 W
  • US 2618496 P

Abstract (en)

[origin: WO9811108A1] The present invention relates to carbapenem antibacterial agents in which the carbapenem nucleus is substituted at the 2-position with a sulfonamide containing ring system linked to the carbapenem nucleus through a CH2 group. The compounds are represented by formula (I) including pharmaceutically acceptable salts thereof, wherein: R<1> represents H or methyl; CO2M represents a carboxylic acid, a carboxylate anion, a pharmaceutically acceptable ester group or a carboxylic acid protected by a protecting group; P represents hydrogen, hydroxyl, F or hydroxyl protected by a hydroxyl-protecting group; X<1> and X<2> represent hydrogen or X<1> and X<2> taken together represent a carbonyl group; and one of AB, BC and CD represents a fused aryl, heteroaryl or heteroarylium ring, and the other variables represent R, said fused aryl, heteroaryl or heteroarylium ring being substituted with from 1-4 R groups. Pharmaceutical compositions and methods of use are also included.

IPC 1-7 (main, further and additional classification)

C07D 487/04; A61K 31/395

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); A61K 31/428 (2006.01); A61K 31/4439 (2006.01); A61K 31/497 (2006.01); A61K 31/4995 (2006.01); A61P 31/04 (2006.01); C07D 477/14 (2006.01); C07D 519/00 (2006.01)

CPC (invention and additional information)

C07D 477/14 (2013.01); Y02P 20/55 (2015.11)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9811108 A1 19980319; AU 4184497 A 19980402; CA 2264147 A1 19980319; EP 1021445 A1 20000726; EP 1021445 A4 20010207; JP 2001500862 A 20010123

INPADOC legal status

2001-10-24 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010326

2001-02-07 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20001229

2001-02-07 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2000-07-26 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 19990412

2000-07-26 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE