Global Patent Index - EP 1021461 A1

EP 1021461 A1 2000-07-26 - USE OF NEURONAL AND LYMPHOCYTIC POTASSIUM CANAL INHIBITORS FOR TREATING NEUROLOGICAL DISEASES OF IMMUNE ORIGIN

Title (en)

USE OF NEURONAL AND LYMPHOCYTIC POTASSIUM CANAL INHIBITORS FOR TREATING NEUROLOGICAL DISEASES OF IMMUNE ORIGIN

Title (de)

VERWENDUNG VON BLOCKERN NEURONALER UND LYMPHOZYTÄRER KALIUMKANÄLE ZUR BEHANDLUNG VON NEUROLOGISCHEN KRANKHEITEN DES IMMUNSYSTEMS

Title (fr)

UTILISATION DES BLOQUEURS DES CANAUX POTASSIUM NEURONAUX ET LYMPHOCYTAIRES DANS LE TRAITEMENT DES MALADIES NEUROLOGIQUES D'ORIGINE IMMUNITAIRE

Publication

EP 1021461 A1 (FR)

Application

EP 98949027 A

Priority

  • FR 9802136 W
  • FR 9712421 A

Abstract (en)

[origin: FR2769226A1] The following are claimed: (1) use of compounds that block neuronal potassium channels of the Kv1.1, Kv1.2 and optionally KV1.3 type to prepare therapeutics for treating human or animal neurological disorders, optionally of immune origin, in which nerve signal transmission is blocked; (2) kaliotoxin 3 having the amino acid sequence (I); (3) peptides of formula (II): Val Gly Ile Pro Val Ser Cys Lys His Ser Gly Gln Cys Ile Lys Pro Cys Lys Asp Ala Gly Met Arg Phe Gly Lys Cys Met Asn Arg Lys Cys Asp Cys Thr Pro Lys (I) Xaa1 Xaa2 Xaa3 Xaa4 Xaa5 Xaa6 Xaa7 Cys Xaa9 Xaa10 Ser Xaa12 Gln Cys Xaa15 Lys Xaa17 Cys Lys Asp Ala Xaa22 Gly Xaa24 Arg Phe Gly Lys Cys Xaa31 Asn Xaa33 Lys Cys Xaa36 Cys Xaa38 Xaa39 Xaa40 (III) Xaa1-Xaa7, Xaa9, Xaa10, Xaa12, Xaa15, Xaa17, Xaa22, Xaa24, Xaa31, Xaa33, Xaa36 and Xaa38-Xaa40 are any natural or unnatural amino acids, provided that: Xaa12 = aminobutyric acid (Abu) or Lys, and/or Xaa17 = Abu or Val, and/or Xaa22 = Phe or is absent, and/or Xaa24 and Xaa 31 = Met or Nle.

IPC 1-7 (main, further and additional classification)

C07K 14/435; A61K 38/17

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61K 35/56 (2006.01); A61K 35/64 (2006.01); A61K 38/17 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); C07K 14/435 (2006.01)

CPC (invention and additional information)

A61K 38/17 (2013.01); C07K 14/43522 (2013.01); C07K 14/43595 (2013.01)

Citation (search report)

See references of WO 9918123A1

Designated contracting state (EPC)

DE FR GB IT

EPO simple patent family

FR 2769226 A1 19990409; FR 2769226 B1 20000602; AU 9544298 A 19990427; CA 2305786 A1 19990415; EP 1021461 A1 20000726; JP 2001519356 A 20011023; WO 9918123 A1 19990415

INPADOC legal status


2004-11-24 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040401

2000-07-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000404

2000-07-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): DE FR GB IT