Global Patent Index - EP 1021537 A1

EP 1021537 A1 2000-07-26 - T CELL RECEPTOR-ASSOCIATED MOLECULES (TRAMS) AND METHODS OF USE THEREFOR

Title (en)

T CELL RECEPTOR-ASSOCIATED MOLECULES (TRAMS) AND METHODS OF USE THEREFOR

Title (de)

MOLEKÜLE, DIE MIT DEM T-ZELL REZEPTOR ASSSOZIIERT SIND (TRAMS), UND VERFAHREN ZUEREN VERWENDUNG

Title (fr)

MOLECULES ASSOCIEES AU RECEPTEUR DES LYMPHOCYTES T (TRAM) ET LEUR MODE D'UTILISATION

Publication

EP 1021537 A1 (EN)

Application

EP 98951056 A

Priority

  • US 9821559 W
  • US 94901497 A

Abstract (en)

[origin: WO9919484A1] Isolated nucleic acid molecules encoding proteins that associate with the T cell receptor complex, termed TRAM-1 and TRAM-2, are disclosed. In addition to isolated nucleic acids molecules encoding TRAM-1 and TRAM-2 proteins, the invention provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a TRAM transgene. The invention further provides isolated TRAM-1 and TRAM-2 proteins and peptides, TRAM-1 and TRAM-2 fusion proteins and anti-TRAM-1 and anti-TRAM-2 antibodies. Methods of using the TRAM compositions of the invention are also disclosed, including methods for detecting TRAM activity in a biological sample, methods of modulating TRAM activity in a cell, and methods for identifying agents that modulate an interaction between a TRAM protein and T cell molecules.

IPC 1-7 (main, further and additional classification)

C12N 15/12; A01K 67/027; A61K 31/70; C07K 14/705; C07K 16/28; C12Q 1/68; G01N 33/53; G01N 33/68

IPC 8 full level (invention and additional information)

A01K 67/027 (2006.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 37/02 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

C07K 14/705 (2013.01); A01K 2217/05 (2013.01); C07K 2319/02 (2013.01)

Citation (search report)

See references of WO 9919484A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9919484 A1 19990422; AU 9694798 A 19990503; EP 1021537 A1 20000726; JP 2001520013 A 20011030

INPADOC legal status


2003-11-05 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20030503

2000-07-26 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000428

2000-07-26 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-07-26 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Free text: RO PAYMENT 20000428;SI PAYMENT 20000428