EP 1021537 A1 20000726 - T CELL RECEPTOR-ASSOCIATED MOLECULES (TRAMS) AND METHODS OF USE THEREFOR
Title (en)
T CELL RECEPTOR-ASSOCIATED MOLECULES (TRAMS) AND METHODS OF USE THEREFOR
Title (de)
MOLEKÜLE, DIE MIT DEM T-ZELL REZEPTOR ASSSOZIIERT SIND (TRAMS), UND VERFAHREN ZUEREN VERWENDUNG
Title (fr)
MOLECULES ASSOCIEES AU RECEPTEUR DES LYMPHOCYTES T (TRAM) ET LEUR MODE D'UTILISATION
Publication
Application
Priority
- US 9821559 W 19981013
- US 94901497 A 19971010
Abstract (en)
[origin: WO9919484A1] Isolated nucleic acid molecules encoding proteins that associate with the T cell receptor complex, termed TRAM-1 and TRAM-2, are disclosed. In addition to isolated nucleic acids molecules encoding TRAM-1 and TRAM-2 proteins, the invention provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a TRAM transgene. The invention further provides isolated TRAM-1 and TRAM-2 proteins and peptides, TRAM-1 and TRAM-2 fusion proteins and anti-TRAM-1 and anti-TRAM-2 antibodies. Methods of using the TRAM compositions of the invention are also disclosed, including methods for detecting TRAM activity in a biological sample, methods of modulating TRAM activity in a cell, and methods for identifying agents that modulate an interaction between a TRAM protein and T cell molecules.
IPC 1-7
C12N 15/12; C07K 14/705; G01N 33/53; G01N 33/68; C12Q 1/68; A61K 31/70; C07K 16/28; A01K 67/027
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/711 (2006.01); A61K 38/00 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 37/02 (2006.01); C07K 14/47 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C12N 1/15 (2006.01); C12N 1/19 (2006.01); C12N 1/21 (2006.01); C12N 5/10 (2006.01); C12N 15/09 (2006.01); C12N 15/12 (2006.01); C12P 21/02 (2006.01); C12P 21/08 (2006.01); C12Q 1/02 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); G01N 33/53 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
A61P 37/02 (2017.12); C07K 14/705 (2013.01); A01K 2217/05 (2013.01); C07K 2319/02 (2013.01)
Citation (search report)
See references of WO 9919484A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9919484 A1 19990422; AU 9694798 A 19990503; EP 1021537 A1 20000726; JP 2001520013 A 20011030
DOCDB simple family (application)
US 9821559 W 19981013; AU 9694798 A 19981013; EP 98951056 A 19981013; JP 2000516036 A 19981013