EP 1023045 A2 20000802 - DELIVERY VEHICLES FOR BIOACTIVE AGENTS AND USES THEREOF
Title (en)
DELIVERY VEHICLES FOR BIOACTIVE AGENTS AND USES THEREOF
Title (de)
VERABREICHUNGSTRÄGER FÜR BIOAKTIVEN WIRKSTOFFEN UND IHRE VERWENDUNG
Title (fr)
VEHICULES DE FOURNITURE D'AGENTS BIOACTIFS ET LEURS UTILISATIONS
Publication
Application
Priority
- US 9822552 W 19981023
- US 6311497 P 19971024
- US 95669497 A 19971024
Abstract (en)
[origin: WO9921533A2] Compositions for transporting a bioactive agent across a biological membrane include the bioactive agent, an oil, an oil-immiscible compound and a noncationic surface active agent. The compositions may deliver the bioactive agent through a chemical microporulation mechanism, which allows transfer of the agent across both cellular, intracellular organelle, and nuclear membranes. Compositions for nucleic acid delivery include nucleic acid, oil, oil-immiscible compound, noncationic surface active agent and essentially no cationic lipid, or include nucleic acid, oil, oil-immiscible compound and two noncationic surface active agents. The nucleic acid may be hydrophobically-modified, and be in combination with an oil, an oil-immiscible compound and at least one surface active agent. The compositions may be used for gene delivery to a cell, as well as delivery of other therapeutic agent.
IPC 1-7
IPC 8 full level
A61K 9/107 (2006.01)
CPC (source: EP)
A61K 9/1075 (2013.01)
Citation (search report)
See references of WO 9921533A2
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE
DOCDB simple family (publication)
WO 9921533 A2 19990506; WO 9921533 A3 19990708; AU 1198599 A 19990517; CA 2306090 A1 19990506; EP 1023045 A2 20000802
DOCDB simple family (application)
US 9822552 W 19981023; AU 1198599 A 19981023; CA 2306090 A 19981023; EP 98955098 A 19981023