Global Patent Index - EP 1023060 A1

EP 1023060 A1 2000-08-02 - UPREGULATION OF TYPE III ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE BY HMG-CoA REDUCTASE INHIBITORS

Title (en)

UPREGULATION OF TYPE III ENDOTHELIAL CELL NITRIC OXIDE SYNTHASE BY HMG-CoA REDUCTASE INHIBITORS

Title (de)

REGULIERUNG VON TYP-III ENDOTHELZELLEN STICKOXID-SYNTHASEN DURCH HMG-COA-REDUCTASE INHIBITOREN

Title (fr)

REGULATION POSITIVE DE L'OXYDE NITRIQUE SYNTHASE DE CELLULES ENDOTHELIALES DE TYPE III PAR DES INHIBITEURS DE LA HMG-CoA REDUCTASE

Publication

EP 1023060 A1 (EN)

Application

EP 98951041 A

Priority

  • US 9821464 W
  • US 6209397 P
  • US 13284898 A

Abstract (en)

[origin: WO9918952A1] A new use for HMG-CoA reductase inhibitors is provided. In the instant invention, HMG-CoA reductase inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase activity through a mechanism other than preventing the formation of oxidative-LDL. As a result, HMG-CoA reductase inhibitors are useful in treating or preventing conditions that result from the abnormally low expression and/or activity of endothelial cell Nitric Oxide Synthase. Such conditions include pulmonary hypertension, ischemic stroke, impotence, heart failure, hypoxia-induced conditions, insulin deficiency, progressive renal disease, gastric or esophageal motility syndrome, etc. Subjects thought to benefit mostly from such treatments include nonhyperlipidemics and nonhypercholesterolemics, but not necessarily exclude hyperlipidemics and hypercholesterolemics.

IPC 1-7 (main, further and additional classification)

A61K 31/35

IPC 8 full level (invention and additional information)

A61K 45/00 (2006.01); A61K 31/00 (2006.01); A61K 31/195 (2006.01); A61K 31/35 (2006.01); A61K 31/365 (2006.01); A61P 1/00 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 13/12 (2006.01); A61P 15/10 (2006.01); A61P 43/00 (2006.01)

CPC (invention and additional information)

A61K 31/35 (2013.01)

Citation (search report)

See references of WO 9918952A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9918952 A1 19990422; WO 9918952 B1 19990527; AU 9693498 A 19990503; CA 2307929 A1 19990422; EP 1023060 A1 20000802; JP 2001519388 A 20011023; US 6147109 A 20001114

INPADOC legal status


2005-06-08 [18W] WITHDRAWN

- Ref Legal Event Code: 18W

- Effective date: 20050418

2004-05-26 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

- Ref Legal Event Code: RAP1

2004-05-26 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: THE GENERAL HOSPITAL CORPORATION

- Ref Legal Event Code: RAP1

2002-07-03 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020522

2000-08-02 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000512

2000-08-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

2000-08-02 [AX] REQUEST FOR EXTENSION OF THE EUROPEAN PATENT TO

- Ref Legal Event Code: AX

- Free Format Text: AL PAYMENT 20000512;LT PAYMENT 20000512;LV PAYMENT 20000512;MK PAYMENT 20000512;RO PAYMENT 20000512;SI PAYMENT 20000512