Global Patent Index - EP 1023068 A1

EP 1023068 A1 2000-08-02 - ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Title (en)

ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS

Title (de)

ALPHA 1a ADRENOREZEPTOR-ANTAGONISTEN

Title (fr)

ANTAGONISTES DES ADRENORECEPTEURS ALPHA 1a

Publication

EP 1023068 A1 (EN)

Application

EP 98930307 A

Priority

  • GB 9800217 A
  • US 9812567 W
  • US 5095997 P

Abstract (en)

[origin: WO9857638A1] This invention relates to certain novel compounds and derivates thereof, their synthesis, and their use as alpha 1a adrenergic receptor antogonists. One application of these compounds is in the treatment of benign prostatic hyperplasia. These compounds are selective in their ability to relax smooth muscle tissue enriched in the alpha 1a receptor subtype without at the same time inducing hypotension. One such tissue is found surrounding the urethral lining. Therefore, one utility of the instant compounds is to provide acute relief to males suffering from benign prostatic hyperplasia, by permitting less hindered urine flow. Another utility of the instant compounds is provided by combination with a human 5-alpha reductase inhibitory compound, such that both acute and chronic relief from the effects of benign prostatic hyperplasia are achieved.

IPC 1-7 (main, further and additional classification)

A61K 31/445; A61K 31/505; C07D 211/18; C07D 239/34; C07D 401/12; C07D 411/12; C07D 413/12; C07D 487/04; C07D 491/08

IPC 8 full level (invention and additional information)

C07D 487/04 (2006.01); A61K 31/451 (2006.01); A61K 31/454 (2006.01); A61K 31/513 (2006.01); A61K 31/519 (2006.01); A61P 13/02 (2006.01); A61P 13/08 (2006.01); A61P 43/00 (2006.01); C07D 211/58 (2006.01); C07D 265/32 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/12 (2006.01); C07D 405/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 491/04 (2006.01); C07D 491/048 (2006.01); C07D 491/10 (2006.01)

CPC (invention and additional information)

C07D 401/12 (2013.01); C07D 211/58 (2013.01); C07D 265/32 (2013.01); C07D 401/14 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 491/04 (2013.01); C07D 491/10 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

EPO simple patent family

WO 9857638 A1 19981223; AU 7972698 A 19990104; CA 2294590 A1 19981223; EP 1023068 A1 20000802; EP 1023068 A4 20010516; JP 2002511085 A 20020409

INPADOC legal status


2002-03-06 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20010705

2001-05-16 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20010404

2001-05-16 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

2001-05-16 [RIC1] CLASSIFICATION (CORRECTION)

- Ref Legal Event Code: RIC1

- Free Format Text: 7A 61K 31/445 A, 7A 61K 31/505 B, 7C 07D 211/18 B, 7C 07D 239/34 B, 7C 07D 491/08 B, 7C 07D 487/04 B, 7C 07D 401/12 B, 7C 07D 411/12 B, 7C 07D 413/12 B, 7C 07D 413/14 B, 7C 07D 401/14 B, 7C 07D 417/14 B, 7C 07D 403/12 B, 7C 07D 211/58 B, 7C 07D 417/12 B, 7C 07D 405/14 B, 7C 07D 491/04 B, 7A 61P 15/10 B

2000-08-02 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000118

2000-08-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE