Title (en)

USE OF THE P-TEN SUPPRESSOR GENE IN DIAGNOSIS AND TREATMENT OF CANCER

Title (de)

VERWENDUNG DES P-TEN TUMOR UNTER DRUCKUNGSGENS ZUR KREBS DIAGNOSE UND BEHANDLUNG

Title (fr)

UTILISATION DU GENE SUPPRESSEUR DE TUMEUR P-TEN DANS LE DIAGNOSTIC ET LE TRAITEMENT DE CANCER

Publication

EP 1023076 A1 20000802 (EN)

Application

EP 98908523 A 19980206

Priority

• US 9802615 W 19980206
• US 3694397 P 19970207

Abstract (en)

[origin: WO9834624A1] This invention provides a nucleic acid encoding P-TEN or an altered form thereof. This invention also provides a purified P-TEN or an altered form thereof. This invention further provides the above-described P-TENs, wherein the P-TEN has an altered, truncated, or deleted phosphatase domain. Further, this invention provides a method of diagnosing whether a patient has cancer which comprises detecting the presence in a suitable sample from the patient of either an altered form of P-TEN or a nucleic acid encoding an altered form of P-TEN. Further, this invention provides a method of identifying a chemical compound which may be useful as a drug for the treatment of cancer which comprises testing compounds for effects on P-TEN activity and identifying compounds which exhibit such an effect.

IPC 1-7

A61K 31/70; A61K 38/17; C07H 21/04; C07K 7/00; C07K 14/00; C12N 15/12; C12Q 1/68; G01N 33/53

IPC 8 full level

C12N 9/16 (2006.01); C12Q 1/68 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01); A61K 38/00 (2006.01)

CPC (source: EP)

C12N 9/16 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57484 (2013.01); A61K 38/00 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/172 (2013.01); G01N 2333/916 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9834624 A1 19980813; AU 6653698 A 19980826; CA 2280097 A1 19980813; EP 1023076 A1 20000802; EP 1023076 A4 20011121

DOCDB simple family (application)

US 9802615 W 19980206; AU 6653698 A 19980206; CA 2280097 A 19980206; EP 98908523 A 19980206