EP 1023078 A1 20000802 - PRECIPITATION OF GROWTH-FACTOR-ENRICHED FIBRINOGEN CONCENTRATE FROM PLATELET RICH PLASMA
Title (en)
PRECIPITATION OF GROWTH-FACTOR-ENRICHED FIBRINOGEN CONCENTRATE FROM PLATELET RICH PLASMA
Title (de)
AUSFÄLLUNG VON WACHSTUMSFAKTOR ANGEREICHERTEM FIBRINOGENKONZENTRAT AUS BLUTPLÄTTCHEN-REICHEM PLASMA
Title (fr)
PRECIPITATION D'UN CONCENTRE DE FIBRINOGENE ENRICHI D'UN FACTEUR DE CROISSANCE OBTENU A PARTIR DE PLASMA ENRICHI EN PLAQUETTES
Publication
Application
Priority
- US 9821626 W 19981016
- US 6226497 P 19971017
Abstract (en)
[origin: WO9920288A1] Increased fibrinogen yields are obtained by adding a precipitating agent to plasma having a high platelet concentration, such as platelet rich plasma. The precipitating agent may be any of several known agents, including polyethylene glycol and ammonium sulfate. The platelet rich plasma is obtained in the preferred embodiment by subjecting plasma to "soft spin" centrifugation of about 580G. An automatic, multiple decanting and multiple-speed centrifuge is preferably used to separate anti-coagulated whole blood into the platelet rich plasma component and red blood cells. The proteins, preferably fibrinogen, FXIII, and FVIII, in the platelet rich component are precipitated, and the proteins and platelets are then concentrated by further centrifugation.
IPC 1-7
IPC 8 full level
A61K 35/14 (2006.01); A61K 35/16 (2006.01); A61K 38/36 (2006.01); A61K 38/43 (2006.01); A61L 26/00 (2006.01); B01D 17/02 (2006.01); B01D 21/01 (2006.01); B01D 21/26 (2006.01); C07K 1/30 (2006.01); C07K 14/75 (2006.01); C12Q 1/56 (2006.01); G01N 33/50 (2006.01)
CPC (source: EP)
A61K 38/363 (2013.01); A61L 26/0042 (2013.01); A61P 7/04 (2017.12); B01D 17/0217 (2013.01); B01D 17/047 (2013.01); B01D 21/01 (2013.01); B01D 21/26 (2013.01); B01D 21/262 (2013.01); B01D 21/34 (2013.01); G01N 33/5094 (2013.01); B01D 2221/10 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9920288 A1 19990429; CA 2306629 A1 19990429; CN 1113656 C 20030709; CN 1276725 A 20001213; EP 1023078 A1 20000802; EP 1023078 A4 20040929; JP 2001520198 A 20011030
DOCDB simple family (application)
US 9821626 W 19981016; CA 2306629 A 19981016; CN 98810252 A 19981016; EP 98953467 A 19981016; JP 2000516685 A 19981016