Global Patent Index - EP 1023286 A1

EP 1023286 A1 2000-08-02 - BENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS AND THEIR USE

Title (en)

BENZIMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE COMPOUNDS AND THEIR USE

Title (de)

BENZIMIDAZOLE DERIVATE, PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DIE SIE ENTHALTEN UND IHRE VERWENDUNG

Title (fr)

COMPOSES DE TYPE BENZIMIDAZOLE, COMPOSITIONS PHARMACEUTIQUES RENFERMANT DES COMPOSES ET LEUR UTILISATION

Publication

EP 1023286 A1 (EN)

Application

EP 98947406 A

Priority

  • DK 9800432 W
  • DK 116097 A

Abstract (en)

[origin: WO9919323A1] The present invention discloses compounds of general formula (1) wherein, R<11> represents a 5- or 6-membered monocyclic heteroaryl group containing at least one nitrogen, or a 5- or 6-membered monocyclic heteroaryl group containing at least one nitrogen as the N-oxide; one of R<6> and R<7> represents hydrogen, and the other represents R'-C=O or CR'=NOR'', wherein R' and R'' each independently may be hydrogen, C1-8-alkyl which may be substituted one or more times with OH, C2-6-alkenyl which may be substituted one or more times with OH, C2-6-alkynyl which may be substituted one or more times with OH, or phenyl which may be substituted one or more times with OH; provided however that when R'' represents hydrogen, C1-8-alkyl, C2-6-alkenyl or C2-6-alkynyl then R<11> represents a 5- or 6-membered monocyclic heteroaryl containing at least one nitrogen as the N-oxide; or a pharmaceutically acceptable salt thereof. The compounds of the invention are useful as GABAA receptor complex modulators.

IPC 1-7 (main, further and additional classification)

C07D 401/10; A61K 31/44; C07C 239/20

IPC 8 full level (invention and additional information)

A61K 31/4427 (2006.01); A61K 31/4439 (2006.01); A61P 25/08 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/28 (2006.01); A61P 43/00 (2006.01); C07C 239/20 (2006.01); C07D 401/10 (2006.01)

CPC (invention and additional information)

C07D 401/10 (2013.01); C07C 239/20 (2013.01)

Citation (search report)

See references of WO 9919323A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9919323 A1 19990422; AU 742172 B2 20011220; AU 9433298 A 19990503; CA 2304379 A1 19990422; CN 1275127 A 20001129; EP 1023286 A1 20000802; JP 2001519429 A 20011023; NZ 503435 A 20011221; TW 424088 B 20010301; ZA 9809238 B 19990517

INPADOC legal status


2002-12-04 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020502

2001-02-14 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: NEUROSEARCH A/S

- Ref Legal Event Code: RAP1

2000-08-02 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000316

2000-08-02 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE