EP 1023316 A2 20000802 - METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES
Title (en)
METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES
Title (de)
METHODEN UND ZUSAMMENSETZUNGEN ZUR LIPIDISIERUNG HYDROPHILER MOLEKÜLE
Title (fr)
PROCEDES ET COMPOSITIONS POUR LA LIPIDATION DE MOLECULES HYDROPHILE
Publication
Application
Priority
- US 9717282 W 19970926
- US 72130696 A 19960926
- US 4949997 P 19970613
Abstract (en)
[origin: WO9813007A2] Fatty acid derivatives of disulfide-containing compounds (for example, disulfide-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in vivo and thus facilitates intracellular or extracellular release of the intact compounds from the fatty acid moieties.
IPC 1-7
IPC 8 full level
A01N 37/18 (2006.01); A61K 9/127 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 43/00 (2006.01); C07C 231/00 (2006.01); C07C 323/00 (2006.01); C07C 323/39 (2006.01); C07C 323/59 (2006.01); C07D 213/71 (2006.01); C07D 473/18 (2006.01); C07H 19/06 (2006.01); C07H 19/16 (2006.01); C07H 21/00 (2006.01); C07J 43/00 (2006.01); C07K 1/00 (2006.01); C07K 5/093 (2006.01); C07K 7/06 (2006.01); C07K 14/00 (2006.01); C07K 14/485 (2006.01); C07K 14/585 (2006.01); C07K 14/62 (2006.01)
IPC 8 main group level
CPC (source: EP KR)
A61K 47/542 (2017.07 - EP); A61P 43/00 (2017.12 - EP); C07C 323/00 (2013.01 - KR); A61K 9/127 (2013.01 - EP); A61K 9/1271 (2013.01 - EP)
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9813007 A2 19980402; WO 9813007 A8 19990520; AU 4596797 A 19980417; AU 737865 B2 20010906; BR 9712128 A 20001212; CA 2267179 A1 19980402; CN 1127477 C 20031112; CN 1235594 A 19991117; EP 1023316 A2 20000802; EP 1023316 A4 20040609; IL 129177 A0 20000217; JP 2002515883 A 20020528; KR 100691315 B1 20070312; KR 20000048608 A 20000725; NO 991465 D0 19990325; NO 991465 L 19990510
DOCDB simple family (application)
US 9717282 W 19970926; AU 4596797 A 19970926; BR 9712128 A 19970926; CA 2267179 A 19970926; CN 97199191 A 19970926; EP 97944483 A 19970926; IL 12917797 A 19970926; JP 51593398 A 19970926; KR 19997002543 A 19990325; NO 991465 A 19990325