Global Patent Index - EP 1023316 A2

EP 1023316 A2 2000-08-02 - METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES

Title (en)

METHODS AND COMPOSITIONS FOR LIPIDIZATION OF HYDROPHILIC MOLECULES

Title (de)

METHODEN UND ZUSAMMENSETZUNGEN ZUR LIPIDISIERUNG HYDROPHILER MOLEKÜLE

Title (fr)

PROCEDES ET COMPOSITIONS POUR LA LIPIDATION DE MOLECULES HYDROPHILE

Publication

EP 1023316 A2 (EN)

Application

EP 97944483 A

Priority

  • US 9717282 W
  • US 72130696 A
  • US 4949997 P

Abstract (en)

[origin: WO9813007A2] Fatty acid derivatives of disulfide-containing compounds (for example, disulfide-containing peptides or proteins) comprising fatty acid-conjugated products with a disulfide linkage are employed for delivery of the compounds to mammalian cells. This modification markedly increases the absorption of the compounds by mammalian cells relative to the rate of absorption of the unconjugated compounds, as well as prolonging blood and tissue retention of the compounds. Moreover, the disulfide linkage in the conjugate is quite labile in vivo and thus facilitates intracellular or extracellular release of the intact compounds from the fatty acid moieties.

IPC 1-7 (main, further and additional classification)

C07K 1/00; A61K 47/48

IPC 8 full level (invention and additional information)

A61K 9/127 (2006.01); A01N 37/18 (2006.01); A61K 31/7088 (2006.01); A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61P 43/00 (2006.01); C07C 231/00 (2006.01); C07C 323/00 (2006.01); C07C 323/39 (2006.01); C07C 323/59 (2006.01); C07D 213/71 (2006.01); C07D 473/18 (2006.01); C07H 19/06 (2006.01); C07H 19/16 (2006.01); C07H 21/00 (2006.01); C07J 43/00 (2006.01); C07K 1/00 (2006.01); C07K 5/093 (2006.01); C07K 7/06 (2006.01); C07K 14/00 (2006.01); C07K 14/485 (2006.01); C07K 14/585 (2006.01); C07K 14/62 (2006.01)

IPC 8 main group level (invention and additional information)

A61K (2006.01); C07C (2006.01)

CPC (invention and additional information)

A61K 47/542 (2017.08); A61K 9/127 (2013.01); A61K 9/1271 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9813007 A2 19980402; WO 9813007 A8 19990520; AU 4596797 A 19980417; AU 737865 B2 20010906; BR 9712128 A 20001212; CA 2267179 A1 19980402; CN 1127477 C 20031112; CN 1235594 A 19991117; EP 1023316 A2 20000802; EP 1023316 A4 20040609; IL 129177 D0 20000217; JP 2002515883 A 20020528; KR 100691315 B1 20070312; KR 20000048608 A 20000725; NO 991465 A 19990510; NO 991465 D0 19990325

INPADOC legal status


2008-11-05 [18R] REFUSED

- Effective date: 20071129

2006-11-08 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050517

2005-06-29 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20050517

2004-06-09 [A4] SUPPLEMENTARY SEARCH REPORT

- Effective date: 20040426

2004-04-14 [R17D] SEARCH REPORT (CORRECTION)

- Effective date: 19980402

2000-08-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 19990422

2000-08-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A2

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE