Global Patent Index - EP 1023324 A1

EP 1023324 A1 2000-08-02 - TRIVALENT THROMBIN INHIBITOR

Title (en)

TRIVALENT THROMBIN INHIBITOR

Title (de)

TRIVALENTE THROMBIN INHIBITORE

Title (fr)

INHIBITEUR DE THROMBINE TRIVALENT

Publication

EP 1023324 A1 (EN)

Application

EP 97944656 A

Priority

CA 9700745 W

Abstract (en)

[origin: WO9919356A1] The present invention relates to a new thrombin inhibitor of formula (I) comprising an S subsite blocking segment (AS), an S' subsite blocking segment (Z), and a fibrinogen recognition exosite blocking segment (P). AS is linked to Z, which is linked to P according to the formula (1): AS-Z-P . The S' subsite blocking segment thus, besides binding to the thrombin S' subsites, connects the S subsite blocking segment and the fibrinogen recognition exosite blocking segment. This binding of Z segment together with the bindings of the AS and P segments, contributes to improve the affinity of the inhibitors significantly.

IPC 1-7 (main, further and additional classification)

C07K 14/815; A61K 38/58

IPC 8 full level (invention and additional information)

A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 7/02 (2006.01); A61P 9/10 (2006.01); C07K 14/815 (2006.01)

CPC (invention and additional information)

C07K 14/815 (2013.01); A61K 38/00 (2013.01)

Citation (search report)

See references of WO 9919356A1

Designated contracting state (EPC)

AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9919356 A1 19990422; AU 4612297 A 19990503; AU 761011 B2 20030529; EP 1023324 A1 20000802; JP 2001519442 A 20011023

INPADOC legal status


2004-08-04 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040127

2003-10-29 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20030916

2000-08-02 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000406

2000-08-02 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE