Global patent index - EP 1025087 A1

EP 1025087 A1 2000-08-09 - SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS

Title (en)

SUBSTITUTED ISOQUINOLINE DERIVATIVES AND THEIR USE AS ANTICONVULSANTS

Title (de)

SUBSTITUIERTE ISOCHINOLINDERIVATE UND IHRE VERWENDUNG ALS ANTICONVULSIVA

Title (fr)

DERIVES D'ISOQUINOLINE SUBSTITUES ET LEUR UTILISATION EN TANT QU'ANTICONVULSIFS

Publication

EP 1025087 A1 (EN)

Application

EP 98949134 A

Priority

  • GB 9803165 W
  • GB 9722537 A
  • GB 9726663 A

Abstract (en)

[origin: WO9921836A1] Novel compounds of formula (I) are useful in the prophylaxis and treatment of anxiety, mania, depression, panic disorders and/or aggression, disorders associated with a subarachnoid haemorrhage or neural shock, the effects associated with withdrawal from substances of abuse such as cocaine, nicotine, alcohol and benzodiazepines, disorders treatable and/or preventable with anti-convulsive agents, such as epilepsy including post-traumatic epilepsy, Parkinson's disease, psychosis, migraine, cerebral ischaemia, Alzheimer's disease and other degenerative diseases such as Huntingdon's chorea, schizophrenia, obsessive compulsive disorders (OCD), neurological deficits associated with AIDS, sleep disorders (including circadian rhythm disorders, insomnia and narcolepsy), tics (e.g. Giles de la Tourette's syndrome), traumatic brain injury, tinnitus, neuralgia, especially trigeminal neuralgia, neuropathic pain, dental pain, cancer pain, inappropriate neuronal activity resulting in neurodysthesias in diseases such as diabetes, multiple sclerosis (MS) and motor neurone disease, ataxias, muscular rigidity (spasticity), temporomandibular joint dysfunction and amyotrophic lateral sclerosis (ALS).

IPC 1-7 (main, further and additional classification)

C07D 217/04; A61K 31/47; C07D 223/16

IPC 8 full level (invention and additional information)

A61K 31/472 (2006.01); A61P 25/00 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/18 (2006.01); A61P 25/20 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); A61P 25/30 (2006.01); A61P 43/00 (2006.01); C07D 217/02 (2006.01); C07D 217/04 (2006.01); C07D 217/06 (2006.01); C07D 223/16 (2006.01)

CPC (invention and additional information)

C07D 223/16 (2013.01); C07D 217/02 (2013.01); C07D 217/04 (2013.01); C07D 217/06 (2013.01)

Citation (search report)

See references of WO 9921836A1

Designated contracting state (EPC)

BE CH DE ES FR GB IT LI NL

EPO simple patent family

WO 9921836 A1 19990506; CA 2307030 A1 19990506; EP 1025087 A1 20000809; JP 2001521026 A 20011106

INPADOC legal status

2003-01-02 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20020629

2002-04-03 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20020218

2000-08-09 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000428

2000-08-09 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): BE CH DE ES FR GB IT LI NL