EP 1025105 A1 20000809 - CONDENSED BENZOTHIOPYRANIC COMPOUNDS
Title (en)
CONDENSED BENZOTHIOPYRANIC COMPOUNDS
Title (de)
KONDENSIERTE BENZOTHIOPYRAN-DERIVATE
Title (fr)
COMPOSES BENZOTHIOPYRANIQUES CONDENSES
Publication
Application
Priority
- EP 9806052 W 19980923
- GB 9720901 A 19971001
Abstract (en)
[origin: WO9916771A1] The use of a compound of formula (I) wherein W is a -CONH-, -SO2- or -CO-; X is -O- or -NR2- in which R2 is C1-C6 alkyl, benzyl, pyridyl or a phenyl ring, the phenyl ring being unsubstituted or substituted by one or two substituents chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R and R1 is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylanino or C1-C6 alkoxy-carbonyl; m is zero or an integer of 1 to 6 and Q is C1-C14 alkyl; or m is zero, 1 or 2 and Q is a phenyl ring or an unsaturated pentatomic heteromonocyclic ring containing two or three heteroatoms chosen independently from oxygen, sulphur and nitrogen, wherein the phenyl ring and the heteromonocyclic ring are unsubstituted or substituted by one or two substituents chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as kynurenine-3-hydroxylase inhibitor is disclosed.
IPC 1-7
IPC 8 full level
A61K 31/38 (2006.01); A61K 31/415 (2006.01); A61P 25/00 (2006.01); A61P 43/00 (2006.01); C07D 495/04 (2006.01); C07D 498/04 (2006.01)
CPC (source: EP)
A61P 25/00 (2017.12); A61P 43/00 (2017.12); C07D 495/04 (2013.01)
Citation (search report)
See references of WO 9916771A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9916771 A1 19990408; AU 9441598 A 19990423; CA 2302027 A1 19990408; EP 1025105 A1 20000809; GB 9720901 D0 19971203; JP 2001518473 A 20011016
DOCDB simple family (application)
EP 9806052 W 19980923; AU 9441598 A 19980923; CA 2302027 A 19980923; EP 98947544 A 19980923; GB 9720901 A 19971001; JP 2000513853 A 19980923