EP 1025116 A1 20000809 - ESTRA-1,3,5(10)-TRIENE-7ALPHA-THIOETHERS
Title (en)
ESTRA-1,3,5(10)-TRIENE-7ALPHA-THIOETHERS
Title (de)
OESTRA-1,3,5(10)-TRIEN-7ALPHA-THIOETHER
Title (fr)
OESTRA-1,3,5(10)-TRIENE-7ALPHA-THIOETHERS
Publication
Application
Priority
- US 9822283 W 19981021
- US 95650997 A 19971023
Abstract (en)
[origin: WO9920646A1] The invention provides estrogens and antiestrogens of formula (I) having structure (I) wherein R is (II), (III), (IV), or (V); R<1> and R<2> are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together to form a 5-7 membered satured heterocycle; X is hydroxy, alkoxy of 1-6 carbon atoms, or -OC(O)R<3>; W is (VI), hydroxy, alkyl of 1-6 carbon atoms, halogen, -CF3, alkoxy of 1-6 carbon atoms, -CHO, cyano, alkylcarbonyl of 2-7 carbon atoms, alkoxycarbonyl of 2-7 carbon atoms, amino, alkylamino of 1-6 carbon atoms, dialkylamino of 1-6 carbon atoms per alkyl group, trifluoromethoxy, hydroxyalkyl of 1-6 carbon atoms, alkoxyalkyl of 2-12 carbon atoms, -CN, -SO3H, or -CO2H; R<3> is alkyl of 1-6 carbon atoms; Z is (VII), (VIII), (IX), or (X); Y is (XI), (XII), or (XIII); R<4> is hydrogen, alkyl of 1-6 carbon atoms, alkoyl of 2-7 carbon atoms, or benzoyl; Q is hydrogen, -OR<5>, or -NR<6>R<7>; R<5> is hydrogen or alkyl of 1-6 carbon atoms; R<6> and R<7> are each, independently, alkyl of 1-6 carbon atoms, or are alkyl groups which are taken together to form a 5-7 membered saturated heterocycle; n = 4-12; and p = 2-6; or a pharmaceutically acceptable salt thereof.
IPC 1-7
IPC 8 full level
A61K 31/565 (2006.01); A61K 31/566 (2006.01); A61K 31/59 (2006.01); A61P 9/00 (2006.01); A61P 11/00 (2006.01); A61P 17/06 (2006.01); A61P 19/00 (2006.01); A61P 19/02 (2006.01); A61P 25/00 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); A61P 31/06 (2006.01); A61P 31/20 (2006.01); A61P 37/06 (2006.01); C07J 31/00 (2006.01); C07J 41/00 (2006.01); C07J 43/00 (2006.01)
CPC (source: EP)
A61P 9/00 (2017.12); A61P 11/00 (2017.12); A61P 17/06 (2017.12); A61P 19/00 (2017.12); A61P 19/02 (2017.12); A61P 25/00 (2017.12); A61P 25/28 (2017.12); A61P 29/00 (2017.12); A61P 31/06 (2017.12); A61P 31/20 (2017.12); A61P 37/06 (2017.12); C07J 31/006 (2013.01); C07J 41/0072 (2013.01); C07J 43/003 (2013.01)
Citation (search report)
See references of WO 9920646A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU NL PT SE
DOCDB simple family (publication)
WO 9920646 A1 19990429; AU 1110699 A 19990510; CA 2308773 A1 19990429; EP 1025116 A1 20000809; JP 2001520235 A 20011030
DOCDB simple family (application)
US 9822283 W 19981021; AU 1110699 A 19981021; CA 2308773 A 19981021; EP 98953837 A 19981021; JP 2000516987 A 19981021