EP 1025118 A1 20000809 - SPACER PEPTIDES AND MEMBRANES CONTAINING SAME
Title (en)
SPACER PEPTIDES AND MEMBRANES CONTAINING SAME
Title (de)
SPACERPEPTIDE UND DIESE ENTHALTENDE MEMBRANEN
Title (fr)
PEPTIDES ESPACEURS ET MEMBRANES CONTENANT CES PEPTIDES
Publication
Application
Priority
- EP 98954352 A 19981006
- EP 9806344 W 19981006
- EP 97118326 A 19971022
Abstract (en)
[origin: WO9920649A1] Synthetic cell membranes which are bonded to a noble metal support and which comprise novel spacer peptides of formula (I) are disclosed. These membranes can incorporate membrane proteins and can be used in biosensing devices. Peptides or peptide-analogous compounds of the formula (I) are disclosed, X-L<N>-A<N>-B-A<C>-L<C>-Y in which preferred embodiments have the following meaning: a) group X contains at least one sulphur atom, e.g. group X represents a Lip group or a group like HS-(CH2)2-CO-; groups A<N> and L<N> both represent single bonds; group A<C> represents Pro Xaa<1> Xaa<1>; group L<C> represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain omega -amino acid like 6-aminocaproic acid; group Y represents Lys(Myr)-Lys(Myr), where Myr represents a myristoyl residue bound to the side chain amino group of Lys; or b) group X represents Myr-Lys(Myr), where Myr represents myristoyl residues bound to the amino groups of Lys; group L<N> represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain omega -amino acid like 6-aminocaproic acid; groups A<N> represents Pro Xaa<1> Xaa<1>; groups A<C> and L<C> both represent single bonds; group Y contains at least one sulphur atom, e.g. group Y represents Cys-amide or group like -NH-(CH2)2-SH.
IPC 1-7
IPC 8 full level
G01N 33/50 (2006.01); C07K 7/02 (2006.01); C07K 7/06 (2006.01); C07K 17/14 (2006.01); G01N 33/15 (2006.01); G01N 33/553 (2006.01); G01N 33/68 (2006.01)
CPC (source: EP)
B82Y 5/00 (2013.01); B82Y 15/00 (2013.01); B82Y 30/00 (2013.01); C07K 7/02 (2013.01); C07K 7/06 (2013.01); C07K 17/14 (2013.01)
Citation (search report)
See references of WO 9920649A1
Designated contracting state (EPC)
DE FR GB
DOCDB simple family (publication)
WO 9920649 A1 19990429; EP 1025118 A1 20000809; JP 2001520236 A 20011030
DOCDB simple family (application)
EP 9806344 W 19981006; EP 98954352 A 19981006; JP 2000516989 A 19981006