Global Patent Index - EP 1025118 A1

EP 1025118 A1 2000-08-09 - SPACER PEPTIDES AND MEMBRANES CONTAINING SAME

Title (en)

SPACER PEPTIDES AND MEMBRANES CONTAINING SAME

Title (de)

SPACERPEPTIDE UND DIESE ENTHALTENDE MEMBRANEN

Title (fr)

PEPTIDES ESPACEURS ET MEMBRANES CONTENANT CES PEPTIDES

Publication

EP 1025118 A1 (EN)

Application

EP 98954352 A

Priority

  • EP 98954352 A
  • EP 9806344 W
  • EP 97118326 A

Abstract (en)

[origin: WO9920649A1] Synthetic cell membranes which are bonded to a noble metal support and which comprise novel spacer peptides of formula (I) are disclosed. These membranes can incorporate membrane proteins and can be used in biosensing devices. Peptides or peptide-analogous compounds of the formula (I) are disclosed, X-L<N>-A<N>-B-A<C>-L<C>-Y in which preferred embodiments have the following meaning: a) group X contains at least one sulphur atom, e.g. group X represents a Lip group or a group like HS-(CH2)2-CO-; groups A<N> and L<N> both represent single bonds; group A<C> represents Pro Xaa<1> Xaa<1>; group L<C> represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain omega -amino acid like 6-aminocaproic acid; group Y represents Lys(Myr)-Lys(Myr), where Myr represents a myristoyl residue bound to the side chain amino group of Lys; or b) group X represents Myr-Lys(Myr), where Myr represents myristoyl residues bound to the amino groups of Lys; group L<N> represents a single bond or an oligomer (number of monomers between 2 and 4) of a medium chain omega -amino acid like 6-aminocaproic acid; groups A<N> represents Pro Xaa<1> Xaa<1>; groups A<C> and L<C> both represent single bonds; group Y contains at least one sulphur atom, e.g. group Y represents Cys-amide or group like -NH-(CH2)2-SH.

IPC 1-7 (main, further and additional classification)

C07K 7/06; C07K 7/02; C07K 17/14; G01N 33/553; G01N 33/68

IPC 8 full level (invention and additional information)

G01N 33/50 (2006.01); C07K 7/02 (2006.01); C07K 7/06 (2006.01); C07K 17/14 (2006.01); G01N 33/15 (2006.01); G01N 33/553 (2006.01); G01N 33/68 (2006.01)

CPC (invention and additional information)

B82Y 30/00 (2013.01); B82Y 5/00 (2013.01); B82Y 15/00 (2013.01); C07K 7/02 (2013.01); C07K 7/06 (2013.01); C07K 17/14 (2013.01)

Citation (search report)

See references of WO 9920649A1

Designated contracting state (EPC)

DE FR GB

EPO simple patent family

WO 9920649 A1 19990429; EP 1025118 A1 20000809; JP 2001520236 A 20011030

INPADOC legal status


2004-11-17 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20040430

2000-08-09 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000226

2000-08-09 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): DE FR GB