EP 1025128 A1 20000809 - DNA MOLECULES ENCODING IMIDAZOLINE RECEPTIVE POLYPEPTIDES AND POLYPEPTIDES ENCODED THEREBY
Title (en)
DNA MOLECULES ENCODING IMIDAZOLINE RECEPTIVE POLYPEPTIDES AND POLYPEPTIDES ENCODED THEREBY
Title (de)
DNA MOLEKÜLE KODIEREND FÜR IMIDAZOLIN REZEPTIVE POLYPEPTIDE
Title (fr)
MOLECULES D'ADN CODANT DES POLYPEPTIDES RECEPTIFS A L'IMIDAZOLINE ET POLYPEPTIDES CODES PAR CET ADN
Publication
Application
Priority
US 9715695 W 19970903
Abstract (en)
[origin: WO9911668A1] A genomic DNA encoding a human imidazoline receptor is described. cDNAs encoding the receptor and fragments thereof are also provided. An amino acid sequence predicted to be 120,000 MW for nearly the entire protein is identified, as well as a middle fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Methods of preparing antibodies against the transfected protein are also described. Also, a screening method for identifying additional subtypes of this receptor are identified. Also, screening methods for identifying drugs that interact with the imidazoline receptor are described.
IPC 1-7
IPC 8 full level
C07K 14/705 (2006.01)
CPC (source: EP)
C07K 14/705 (2013.01)
Citation (search report)
See references of WO 9911668A1
Designated contracting state (EPC)
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9911668 A1 19990311; AU 4334897 A 19990322; CA 2303419 A1 19990311; EP 1025128 A1 20000809
DOCDB simple family (application)
US 9715695 W 19970903; AU 4334897 A 19970903; CA 2303419 A 19970903; EP 97941441 A 19970903