EP 1025225 A1 20000809 - P-40/ANNEXIN I AND RELATED PROTEINS AND THEIR ROLE IN MULTIDRUG RESISTANCE
Title (en)
P-40/ANNEXIN I AND RELATED PROTEINS AND THEIR ROLE IN MULTIDRUG RESISTANCE
Title (de)
P-40/ANNEXIN I UND VERWANDTE PROTEINE UND DEREN ROLLE IN MULTIDROGENRESISTENZ
Title (fr)
P-40/ANNEXINE I, PROTEINES ASSOCIEES ET LEUR ROLE DANS LA RESISTANCE MULTIPLE AUX ANTICANCEREUX
Publication
Application
Priority
- CA 9800992 W 19981026
- CA 2219299 A 19971024
Abstract (en)
[origin: WO9921980A1] The present invention relates in general to multidrug resistance (MDR) in cells. In particular, the present invention relates to the identification of a new member of the MDR gene family, P-40, as well as to the identification of P-40 related genes (homologs) as being additional members of the MDR gene family. The present invention therefore relates to nucleic acid molecules encoding P-40 protein and P-40 protein homologs, to multidrug resistant cells containing these nucleic acid molecules; to hybridomas containing antibodies to P-40 and P-40 homologs; to nucleic acid probes for the detection of these nucleic acid molecules; to a method of detection of such nucleic acid molecules or of the P-40 protein or P-40 homologs, to bioassays comprising the nucleic acid molecules encoding P-40 or P-40 homologs, P-40 protein or P-40 protein homologs, or antibodies of the present invention to diagnose, assess or prognose MDR in an animal; to therapeutic uses of the nucleic acid molecules of the present invention (i.e. antisense), protein or antibodies of the present invention; and to methods of preventing MDR in an animal.
IPC 1-7
C12N 15/12; C07K 14/47; C12Q 1/68; C12N 15/11; A61K 31/70; A61K 39/395; A61K 38/17; G01N 33/50
IPC 8 full level
C07K 14/47 (2006.01); C12N 15/12 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP)
C07K 14/4721 (2013.01); A61K 38/00 (2013.01)
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
WO 9921980 A1 19990506; AU 9617498 A 19990517; CA 2219299 A1 19990424; EP 1025225 A1 20000809
DOCDB simple family (application)
CA 9800992 W 19981026; AU 9617498 A 19981026; CA 2219299 A 19971024; EP 98949842 A 19981026