EP 1025255 A1 20000809 - METHOD FOR PREPARING A SUBSTITUTED BENZAMIDE
Title (en)
METHOD FOR PREPARING A SUBSTITUTED BENZAMIDE
Title (de)
VERFAHREN ZUR HERSTELLUNG EINES SUBSTITUIERTEN BENZAMID
Title (fr)
PROCEDE DE PREPARATION D'UN BENZAMIDE SUBSTITUE
Publication
Application
Priority
- FR 9802274 W 19981023
- FR 9713368 A 19971024
Abstract (en)
[origin: FR2770214A1] Production of halogenated benzamides is effected by enzymatic hydrolysis of halogenated benzonitriles using a Brevibacterium nitrile hydratase defined as being a tetrameric enzyme of structure alpha 2 beta 2 having at least 50%, preferably more than 80%, homology with the amino acid sequences of the alpha chain and the beta chain. MSVTIDHTTENAAPAQAPVSDRAWALFRA LDGKGLVPDGYVEGWKKTFEEDFSPRRGA ELVARAWTDPEFRQLLLTDGTAAVAQYGY LGPQGEYIVAVEDTPTLKNVIVCSLCSCTA WPILGLPPTWYKSFEYRARVVREPRKVLSE MGTEIASDIEIRVYDTTAETRYMVLPQRPAG TEGWSQEQLQEIVTKDCLIGVAIPQVPTV ( alpha chain). MDGVHDLAGVQGFGKVPHTVNADIGPTFH AEWEHLPYSLMFAGVAELGAFSVDEVRYV VERMEPRHYMMTPYYERYVIGVATLMVEK GILTQDELESLAGGPFPLSRPSESEGRPAPVE TTTFEVGQRVRVRDEYVPGHIRMPAYCRGR VGTISHRTTEKWPFPDAIGHGRNDAGEEPTY VKFAAEELFGSDTDGGSVVVDLFEGYLEPAA ( beta chain). Also CLAIMED are: (1) the benzamide produced by the above method; and (2) 2,6-difluorobenzamide obtained by the hydrolysis of 2,6-difluorobenzonitrile, using the above method.
IPC 1-7
IPC 8 full level
C12N 9/78 (2006.01); C07C 233/65 (2006.01); C12P 13/02 (2006.01); C12R 1/13 (2006.01)
CPC (source: EP)
C12P 13/02 (2013.01)
Citation (search report)
See references of WO 9922012A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FR GB IE IT LI NL
DOCDB simple family (publication)
FR 2770214 A1 19990430; FR 2770214 B1 19991231; CN 1277637 A 20001220; EP 1025255 A1 20000809; JP 2001520891 A 20011106; WO 9922012 A1 19990506
DOCDB simple family (application)
FR 9713368 A 19971024; CN 98810505 A 19981023; EP 98951543 A 19981023; FR 9802274 W 19981023; JP 2000518103 A 19981023