EP 1027335 A1 20000816 - ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS

Title (en)

ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS

Title (de)

ORTHO-HYDROXYPYRIDINONE ALS EISENCHELATBILDNER UND ANTIOXIDANTMITTEL

Title (fr)

DERIVES D'ORTHO-HYDROXYPYRIDINONE UTILISES COMME AGENTS CHELATEURS DU FER ET COMME AGENTS ANTIOXYDANTS

Publication

EP 1027335 A1 20000816 (EN)

Application

EP 98950227 A 19981030

Priority

GB 9803244 W 19981030
GB 9723078 A 19971031

Abstract (en)

[origin: WO9923075A1] A compound of formula (1): wherein A is (AI) or (AII) wherein R<1>, R<2> and R<3> are independently selected from H and alkyl; wherein X is O, S, NR<4> or a direct bond, wherein R<4> is H or alkyl; wherein Z is a saturated hydrocarbyl chain comprising from 1 to 10 carbon atoms; wherein q is 1, 2 or 3, wherein if q is 2 or 3, then each A can be the same or different; wherein the or each R<5> is independently selected from H or alkyl; wherein the or each R<6> is independently selected from alkyl; wherein n is 1 to 5; wherein p is 0 to 4; and wherein the sum of n and p is less than 6, or a pharmaceutically acceptable salt thereof, and the therapeutic use thereof, in particular for the treatment of a condition resulting in oxidative stress.

IPC 1-7

C07D 213/69; C07D 405/06; C07D 401/04; A61K 31/44

IPC 8 full level

A61K 31/44 (2006.01); A61K 31/4409 (2006.01); A61K 31/4418 (2006.01); A61K 31/4425 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61P 9/10 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07D 213/69 (2006.01); C07D 401/04 (2006.01); C07D 405/06 (2006.01)

CPC (source: EP)

A61P 9/10 (2017.12); A61P 21/00 (2017.12); A61P 25/00 (2017.12); A61P 25/14 (2017.12); A61P 25/16 (2017.12); A61P 25/28 (2017.12); C07D 213/69 (2013.01); C07D 401/04 (2013.01); C07D 405/06 (2013.01)

Citation (search report)

See references of WO 9923075A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

WO 9923075 A1 19990514; AU 9638098 A 19990524; EP 1027335 A1 20000816; GB 9723078 D0 19980107; JP 2001521924 A 20011113

DOCDB simple family (application)

GB 9803244 W 19981030; AU 9638098 A 19981030; EP 98950227 A 19981030; GB 9723078 A 19971031; JP 2000518950 A 19981030