Global Patent Index - EP 1027335 A1

EP 1027335 A1 2000-08-16 - ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS

Title (en)

ORTHO-HYDROXYPYRIDINONE DERIVATIVES AS IRON CHELATING AND ANTIOXIDANT AGENTS

Title (de)

ORTHO-HYDROXYPYRIDINONE ALS EISENCHELATBILDNER UND ANTIOXIDANTMITTEL

Title (fr)

DERIVES D'ORTHO-HYDROXYPYRIDINONE UTILISES COMME AGENTS CHELATEURS DU FER ET COMME AGENTS ANTIOXYDANTS

Publication

EP 1027335 A1 (EN)

Application

EP 98950227 A

Priority

  • GB 9803244 W
  • GB 9723078 A

Abstract (en)

[origin: WO9923075A1] A compound of formula (1): wherein A is (AI) or (AII) wherein R<1>, R<2> and R<3> are independently selected from H and alkyl; wherein X is O, S, NR<4> or a direct bond, wherein R<4> is H or alkyl; wherein Z is a saturated hydrocarbyl chain comprising from 1 to 10 carbon atoms; wherein q is 1, 2 or 3, wherein if q is 2 or 3, then each A can be the same or different; wherein the or each R<5> is independently selected from H or alkyl; wherein the or each R<6> is independently selected from alkyl; wherein n is 1 to 5; wherein p is 0 to 4; and wherein the sum of n and p is less than 6, or a pharmaceutically acceptable salt thereof, and the therapeutic use thereof, in particular for the treatment of a condition resulting in oxidative stress.

IPC 1-7 (main, further and additional classification)

C07D 213/69; A61K 31/44; C07D 401/04; C07D 405/06

IPC 8 full level (invention and additional information)

A61K 31/44 (2006.01); A61K 31/4409 (2006.01); A61K 31/4418 (2006.01); A61K 31/4425 (2006.01); A61K 31/443 (2006.01); A61K 31/4433 (2006.01); A61P 9/10 (2006.01); A61P 21/00 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07D 213/69 (2006.01); C07D 401/04 (2006.01); C07D 405/06 (2006.01)

CPC (invention and additional information)

C07D 213/69 (2013.01); C07D 401/04 (2013.01); C07D 405/06 (2013.01)

Citation (search report)

See references of WO 9923075A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

WO 9923075 A1 19990514; AU 9638098 A 19990524; EP 1027335 A1 20000816; GB 9723078 D0 19980107; JP 2001521924 A 20011113

INPADOC legal status


2002-11-06 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20020501

2000-09-06 [RAP1] TRANSFER OF RIGHTS OF AN EP PUBLISHED APPLICATION

- Owner name: VERNALIS RESEARCH LIMITED

2000-08-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000428

2000-08-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE