Global Patent Index - EP 1027350 A1

EP 1027350 A1 2000-08-16 - AMINOMETHYL-BENZO A QUINOLIZIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATIONS FOR NEURODEGENRATIVE DISEASES

Title (en)

AMINOMETHYL-BENZO A QUINOLIZIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATIONS FOR NEURODEGENRATIVE DISEASES

Title (de)

AMINOMETHYLBENZOCHINOLIZIDINDERIVATE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ZUR BEHANDLUNG VON NEURODEGENERATIVEN KRANKHEITEN

Title (fr)

DERIVES D'AMINOMETHYL-BENZO A QUINOLIZIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE POUR LES MALADIES NEURODEGENERATIVES

Publication

EP 1027350 A1 (FR)

Application

EP 98951548 A

Priority

  • FR 9802281 W
  • FR 9713499 A

Abstract (en)

[origin: FR2770215A1] Benzo(a)quinolizidine derivatives (I) which are 2-substituted by N-substituted aminomethyl are new. Aminomethyl benzo(a)quinolizidine derivatives of formula (I) are new. R1 = H, halo OH or 1-4C alkyl or 1-4C alkoxy (both optionally cyclized); R2 = H or 1-6C alkyl; R3 = H, alkyl sulfonyl or arylsulfonyl (both optionally substituted) or it forms (C=X)-NR4R5or (C=X)-R6; X = O or S; R4, R5 = H, 1-8C alkyl (optionally cyclized) or aryl, aralkyl, aroyl (all aryl groups optionally substituted) or R4 and R5 may be linked by a carbon chain, optionally containing a heteroatom; or R4 = aralkyl or aryloxyalkyl (the aryl part being optionally substituted and the alkyl part being optionally cyclized); R6 = H, 1-10C alkyl (optionally cyclized, optionally containing a heteroatom, optionally incorporating a double bond that may be conjugated with the C=X carbonyl), 1-8C alkoxy (optionally cyclized), optionally substituted aralkoxy or an aromatic or heteroaromatic group optionally substituted by 1-6C alkyl, 1-6C alkoxy, OH, halogens, nitro, CF3, CN, COCH3, thiophene, furan, pyrrole, pyridine and their benzo-fused derivatives, R6 may further contain aromatic cyclic systems such as 2-indanyl, fluorenyl, coumarinyl or benzopyranyl. aryl = phenyl or naphthyl; heteroaryl = 5- or 6-membered ring containing one or more N, O or S, as well as their benzofused derivatives forming pyridine, furan, thiophene, benzoxazine, quinoxaline, quinazoline, benzimidazole or benzopyrazole.

IPC 1-7 (main, further and additional classification)

C07D 455/06; A61K 31/435

IPC 8 full level (invention and additional information)

A61K 31/4375 (2006.01); A61K 31/4545 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07D 455/06 (2006.01)

CPC (invention and additional information)

C07D 455/06 (2013.01)

Citation (search report)

See references of WO 9921856A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

EPO simple patent family

FR 2770215 A1 19990430; FR 2770215 B1 20000114; AU 9751798 A 19990517; BR 9813303 A 20000829; CA 2307748 A1 19990506; CN 1278260 A 20001227; EP 1027350 A1 20000816; JP 2001521034 A 20011106; WO 9921856 A1 19990506

INPADOC legal status


2007-11-14 [RTI1] TITLE (CORRECTION)

- Free text: AMINOMETHYL-BENZO A QUINOLIZIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATIONS FOR NEURODEGENRATIVE DISEASES

2001-07-25 [18D] DEEMED TO BE WITHDRAWN

- Effective date: 20010202

2000-11-08 [17Q] FIRST EXAMINATION REPORT

- Effective date: 20000921

2000-08-16 [17P] REQUEST FOR EXAMINATION FILED

- Effective date: 20000516

2000-08-16 [AK] DESIGNATED CONTRACTING STATES:

- Kind Code of Ref Document: A1

- Designated State(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE