Global Patent Index - EP 1027350 A1

EP 1027350 A1 20000816 - AMINOMETHYL-BENZO A QUINOLIZIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATIONS FOR NEURODEGENRATIVE DISEASES

Title (en)

AMINOMETHYL-BENZO A QUINOLIZIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC APPLICATIONS FOR NEURODEGENRATIVE DISEASES

Title (de)

AMINOMETHYLBENZOCHINOLIZIDINDERIVATE, IHRE HERSTELLUNG UND IHRE VERWENDUNG ZUR BEHANDLUNG VON NEURODEGENERATIVEN KRANKHEITEN

Title (fr)

DERIVES D'AMINOMETHYL-BENZO A QUINOLIZIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE POUR LES MALADIES NEURODEGENERATIVES

Publication

EP 1027350 A1 20000816 (FR)

Application

EP 98951548 A 19981026

Priority

  • FR 9802281 W 19981026
  • FR 9713499 A 19971028

Abstract (en)

[origin: FR2770215A1] Benzo(a)quinolizidine derivatives (I) which are 2-substituted by N-substituted aminomethyl are new. Aminomethyl benzo(a)quinolizidine derivatives of formula (I) are new. R1 = H, halo OH or 1-4C alkyl or 1-4C alkoxy (both optionally cyclized); R2 = H or 1-6C alkyl; R3 = H, alkyl sulfonyl or arylsulfonyl (both optionally substituted) or it forms (C=X)-NR4R5or (C=X)-R6; X = O or S; R4, R5 = H, 1-8C alkyl (optionally cyclized) or aryl, aralkyl, aroyl (all aryl groups optionally substituted) or R4 and R5 may be linked by a carbon chain, optionally containing a heteroatom; or R4 = aralkyl or aryloxyalkyl (the aryl part being optionally substituted and the alkyl part being optionally cyclized); R6 = H, 1-10C alkyl (optionally cyclized, optionally containing a heteroatom, optionally incorporating a double bond that may be conjugated with the C=X carbonyl), 1-8C alkoxy (optionally cyclized), optionally substituted aralkoxy or an aromatic or heteroaromatic group optionally substituted by 1-6C alkyl, 1-6C alkoxy, OH, halogens, nitro, CF3, CN, COCH3, thiophene, furan, pyrrole, pyridine and their benzo-fused derivatives, R6 may further contain aromatic cyclic systems such as 2-indanyl, fluorenyl, coumarinyl or benzopyranyl. aryl = phenyl or naphthyl; heteroaryl = 5- or 6-membered ring containing one or more N, O or S, as well as their benzofused derivatives forming pyridine, furan, thiophene, benzoxazine, quinoxaline, quinazoline, benzimidazole or benzopyrazole.

IPC 1-7

C07D 455/06; A61K 31/435

IPC 8 full level

A61K 31/4375 (2006.01); A61K 31/4545 (2006.01); A61P 25/00 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07D 455/06 (2006.01)

CPC (source: EP)

A61P 25/00 (2018.01); A61P 25/14 (2018.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); C07D 455/06 (2013.01)

Citation (search report)

See references of WO 9921856A1

Designated contracting state (EPC)

AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

DOCDB simple family (publication)

FR 2770215 A1 19990430; FR 2770215 B1 20000114; AU 9751798 A 19990517; BR 9813303 A 20000829; CA 2307748 A1 19990506; CN 1278260 A 20001227; EP 1027350 A1 20000816; JP 2001521034 A 20011106; WO 9921856 A1 19990506

DOCDB simple family (application)

FR 9713499 A 19971028; AU 9751798 A 19981026; BR 9813303 A 19981026; CA 2307748 A 19981026; CN 98810769 A 19981026; EP 98951548 A 19981026; FR 9802281 W 19981026; JP 2000517966 A 19981026