Global patent index - EP 1027369 A1

EP 1027369 A1 2000-08-16 - METHODS OF UNFOLDING PROTEINS USING METAL COMPLEXES

Title (en)

METHODS OF UNFOLDING PROTEINS USING METAL COMPLEXES

Title (de)

METHODEN ZUM ENTFALTEN VON PROTEINEN UNTER VERWENDUNG VON METALLKOMPLEXEN

Title (fr)

PROCEDES POUR LE DEPLIEMENT DES PROTEINES AU MOYEN DE COMPLEXES METALLIQUES

Publication

EP 1027369 A1 (EN)

Application

EP 98934562 A

Priority

  • US 9814630 W
  • US 5266597 P
  • US 11678298 A

Abstract (en)

[origin: WO9903877A1] The invention relates to methods of unfolding proteins using metal complexes, particularly cobalt-containing Schiff's base compounds. The proteins can be viral proteins or myoglobin, and the unfolding can be irreversible under physiological conditions. The unfolded proteins exhibit UV/vis absorption spectral changes (see the figure) and a 5 % or greater change in at least one minima or maxima of the circular dichroism spectra of the proteins.

IPC 1-7 (main, further and additional classification)

C07K 1/00; C07K 14/005

IPC 8 full level (invention and additional information)

C07K 1/113 (2006.01); C07K 14/805 (2006.01)

CPC (invention and additional information)

C07K 14/805 (2013.01); C07K 1/1136 (2013.01)

Designated contracting state (EPC)

AT BE CH DE DK FR GB IT LI NL SE

EPO simple patent family

WO 9903877 A1 19990128; AU 8405298 A 19990210; CA 2297362 A1 19990128; EP 1027369 A1 20000816; EP 1027369 A4 20020807

INPADOC legal status

2003-08-13 [18D] DEEMED TO BE WITHDRAWN

- Ref Legal Event Code: 18D

- Effective date: 20030131

2003-01-02 [17Q] FIRST EXAMINATION REPORT

- Ref Legal Event Code: 17Q

- Effective date: 20021106

2002-08-07 [A4] SUPPLEMENTARY SEARCH REPORT

- Ref Legal Event Code: A4

- Effective date: 20020625

2002-08-07 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK FR GB IT LI NL SE

2000-08-16 [17P] REQUEST FOR EXAMINATION FILED

- Ref Legal Event Code: 17P

- Effective date: 20000215

2000-08-16 [AK] DESIGNATED CONTRACTING STATES:

- Ref Legal Event Code: AK

- Designated State(s): AT BE CH DE DK FR GB IT LI NL SE