EP 1027429 A1 20000816 - JNK3 MODULATORS AND METHODS OF USE
Title (en)
JNK3 MODULATORS AND METHODS OF USE
Title (de)
JNK3 MODULATOREN UND VERFAHREN ZU IHRER VERWENDUNG
Title (fr)
MODULATEURS DE JNK3 ET LEURS METHODES D'UTILISATION
Publication
Application
Priority
- US 9820904 W 19981005
- US 6099597 P 19971003
Abstract (en)
[origin: WO9918193A1] The c-Jun NH2-terminal kinase (JNK) group of MAP kinases are activated by exposure of cells to environmental stress. The role of JNK in the brain was examined by targeted disruption of the gene that encodes the neuronal isoform JNK3. It was found that JNK3 is required for the normal response to seizure activity. Methods of screening for molecules and compounds that decrease JNK3 expression or activity are described. Such molecules or compounds are useful for treating disorders involving excitotoxicity such as seizure disorders, Alzheimer's disease, Huntington disease, Parkinson's disease, and ischaemia.
IPC 1-7
C12N 15/00; C12N 15/09; C12N 15/63; C12N 5/00; A01N 43/04; A61K 31/70
IPC 8 full level
A01K 67/027 (2006.01); A61K 31/711 (2006.01); A61K 45/00 (2006.01); A61K 48/00 (2006.01); A61P 9/10 (2006.01); A61P 21/00 (2006.01); A61P 25/08 (2006.01); A61P 25/14 (2006.01); A61P 25/16 (2006.01); A61P 25/28 (2006.01); C07K 14/47 (2006.01); C07K 14/82 (2006.01); C12N 5/10 (2006.01); C12N 9/12 (2006.01); C12N 15/09 (2006.01); C12N 15/85 (2006.01); C12Q 1/48 (2006.01); C12Q 1/68 (2006.01); G01N 33/15 (2006.01); G01N 33/50 (2006.01); A61K 38/00 (2006.01)
CPC (source: EP US)
A01K 67/0276 (2013.01 - EP US); A61P 9/10 (2017.12 - EP); A61P 17/02 (2017.12 - EP); A61P 21/00 (2017.12 - EP); A61P 25/00 (2017.12 - EP); A61P 25/02 (2017.12 - EP); A61P 25/08 (2017.12 - EP); A61P 25/14 (2017.12 - EP); A61P 25/16 (2017.12 - EP); A61P 25/28 (2017.12 - EP); A61P 43/00 (2017.12 - EP); C07K 14/4747 (2013.01 - EP US); C07K 14/82 (2013.01 - EP US); C12N 9/1205 (2013.01 - EP US); C12N 15/8509 (2013.01 - EP US); A01K 2217/05 (2013.01 - EP US); A01K 2217/075 (2013.01 - EP US); A01K 2227/105 (2013.01 - EP US); A01K 2267/03 (2013.01 - EP US); A01K 2267/0318 (2013.01 - EP US); A01K 2267/0356 (2013.01 - EP US); A61K 38/00 (2013.01 - EP US)
Designated contracting state (EPC)
DE GB
DOCDB simple family (publication)
WO 9918193 A1 19990415; AU 1186099 A 19990427; AU 756401 B2 20030109; CA 2302874 A1 19990415; CA 2302874 C 20110712; DE 69837931 D1 20070726; DE 69837931 T2 20080221; DE 69841792 D1 20100909; EP 1027429 A1 20000816; EP 1027429 A4 20021120; EP 1027429 B1 20070613; HK 1031128 A1 20010601; JP 2001519146 A 20011023; JP 2010233570 A 20101021; US 2003023990 A1 20030130; US 2006035303 A1 20060216; US 2012240247 A1 20120920; US 6943000 B2 20050913
DOCDB simple family (application)
US 9820904 W 19981005; AU 1186099 A 19981005; CA 2302874 A 19981005; DE 69837931 T 19981005; DE 69841792 T 19981005; EP 98954937 A 19981005; HK 01101146 A 20010216; JP 2000514991 A 19981005; JP 2010095769 A 20100419; US 16552298 A 19981002; US 18004405 A 20050712; US 201113328442 A 20111216