EP 1028711 A1 20000823 - METHOD FOR PRODUCING LIPOSOMES
Title (en)
METHOD FOR PRODUCING LIPOSOMES
Title (de)
VERFAHREN ZUR HERSTELLUNG VON LIPOSOMEN
Title (fr)
PROCEDE DE PRODUCTION DE LIPOSOMES
Publication
Application
Priority
- DE 19748796 A 19971105
- EP 9807046 W 19981104
Abstract (en)
[origin: DE19748796A1] The invention relates to a method for producing liposomes or dispersions of liposomes in an aqueous phase. The invention is characterized in that (I) (a) one lipid or one lipid mixture, (b) one optional oil phase, (c) one aqueous phase, (d) and one or more optional tensides are mixed together and homogenized at a temperature which is above the melting temperature of a lipid or lipid mixture and of the oil phase (in the case that one such oil phase is used). (II) The entirety of the homogenized components (a), (b), (c) and (d) forms a lamellar phase in a temperature interval [ theta ]. (III) The temperature of the homogenized mixture comprised of (a), (b), (c) and (d) is brought to a value within the temperature interval [ theta ] (production temperature theta 1) or to a value above the temperature interval [ theta ] (production temperature theta 2). (IV) Water is added to the homogenized mixture comprised of (a), (b), (c) and (d) and the formed liposomes or the formed liposome dispersion is brought to a temperature theta 3 which is below the temperature interval [ theta ].
IPC 1-7
IPC 8 full level
A61K 9/127 (2006.01)
CPC (source: EP)
A61K 9/1272 (2013.01); A61K 9/1277 (2013.01)
Citation (search report)
See references of WO 9924018A1
Designated contracting state (EPC)
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
DOCDB simple family (publication)
DE 19748796 A1 19990506; EP 1028711 A1 20000823; JP 2001522795 A 20011120; WO 9924018 A1 19990520
DOCDB simple family (application)
DE 19748796 A 19971105; EP 9807046 W 19981104; EP 98958902 A 19981104; JP 2000520111 A 19981104